Hernando de Talavera, O.S.H. (c. 1430 – 14 May 1507) was a Spanish clergyman and councilor to Queen Isabel of Castile. He began his career as a monk of the Order of Saint Jerome, was appointed the queen's confessor and with her support and patronage, became the Archbishop of Granada.
Talavera also served on the royal council and was relied upon to undertake important assignments for the Crown. In 1479 he was sent to Portugal to ensure that Isabel’s rival, Juana of Castile, entered a convent as previously agreed. In 1486, Talavera facilitated an introduction between Christopher Columbus and Isabel, after which the queen instructed Talavera to establish a commission to consider the feasibility of the Columbus proposal.