Hernando de Soto in the context of "Natchez people"

The Mississippian culture was a collection of Native American societies that flourished in what is now the Midwestern, Eastern, and Southeastern United States from approximately 800 to 1600 CE, varying regionally. It was known for building large, earthen platform mounds, and often other shaped mounds as well. It was composed of a series of urban settlements and satellite villages linked together by loose trading networks. The largest city was Cahokia, believed to be a major religious center, located in what is present-day southern Illinois.

The Mississippian way of life began to develop in the Mississippi River Valley (for which it is named). Cultures in the tributary Tennessee River Valley may have also begun to develop Mississippian characteristics at this point. Almost all dated Mississippian sites predate 1539–1540 (when Hernando de Soto explored the area), with notable exceptions being Natchez communities. These maintained Mississippian cultural practices into the 18th century.

The Upper Mississippian cultures were located in the Upper Mississippi basin and Great Lakes region of the American Midwest. They were in existence from approximately A.D. 1000 until the Protohistoric and early Historic periods (approximately A.D. 1700).

Archaeologists generally consider "Upper Mississippian" to be an attenuated version of "Middle Mississippian" cultures represented at Cahokia and other sites exhibiting more complex social and political structures, perhaps at a chiefdom level of development. The Middle Mississippians were capable of forming large cities and were thus heavily dependent on agriculture to support large populations. This civilization had its origins about A.D. 1000 or slightly earlier, and was at its peak in the 12th and 13th centuries A.D. when the population at Cahokia was estimated to be 40,000 and the city itself covered an area of 3,480 acres (in contrast, Upper Mississippian sites are usually well under 10 acres). Although the Middle Mississippian declined after its peak, there were still advanced chiefdom-level societies present at the time of the DeSoto expedition in the 1530s and 1540s.

Memphis is a city in Shelby County, Tennessee, United States, and its county seat. Situated along the Mississippi River, it had a population of 633,104 at the 2020 census, making it the second-most populous city in Tennessee, the fifth-most populous in the Southeast, and the 28th-most populous in the US. Memphis is the largest city proper on the Mississippi River and anchors the Memphis area that includes parts of Arkansas and Mississippi, the 45th-most populous metropolitan area in the U.S. with 1.34 million residents.

European exploration of the area began with Spanish conquistador Hernando de Soto in 1541. Located on the high Chickasaw Bluffs, the site offered natural protection from Mississippi River flooding and became a contested location in the colonial era. Modern Memphis was founded in 1819 by John Overton, James Winchester, and Andrew Jackson. The city thrived due to its river traffic and cotton-based economy, becoming one of the largest cities in the Antebellum South. After the American Civil War, it remained a key hub for the cotton and hardwood industries. Memphis is also notable for its role in the American Civil Rights Movement; Dr. Martin Luther King Jr. was assassinated there in 1968, and the city is now home to the National Civil Rights Museum, a Smithsonian affiliate.