Health technology is defined by the World Health Organization as the "application of organized knowledge and skills in the form of devices, medicines, vaccines, procedures, and systems developed to solve a health problem and improve quality of lives". This includes pharmaceuticals, devices, procedures, and organizational systems used in the healthcare industry, as well as computer-supported information systems. In the United States, these technologies involve standardized physical objects, as well as traditional and designed social means and methods to treat or care for patients.
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👉 Health technology in the context of Gene therapy
Gene therapy is medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells.
The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in phase I. In 2003, Gendicine became the first gene therapy to receive regulatory approval. Since that time, further gene therapy drugs were approved, such as alipogene tiparvovec (2012), Strimvelis (2016), tisagenlecleucel (2017), voretigene neparvovec (2017), patisiran (2018), onasemnogene abeparvovec (2019), idecabtagene vicleucel (2021), nadofaragene firadenovec, valoctocogene roxaparvovec and etranacogene dezaparvovec (all 2022). Most of these approaches utilize adeno-associated viruses (AAVs) and lentiviruses for performing gene insertions, in vivo and ex vivo, respectively. AAVs are characterized by stabilizing the viral capsid, lower immunogenicity, ability to transduce both dividing and nondividing cells, the potential to integrate site specifically and to achieve long-term expression in the in-vivo treatment. ASO / siRNA approaches such as those conducted by Alnylam and Ionis Pharmaceuticals require non-viral delivery systems, and utilize alternative mechanisms for trafficking to liver cells by way of GalNAc transporters.
In this Dossier
Health technology in the context of Siemens
Siemens AG (German pronunciation: [ˈziːməns] or [-mɛns]) is a German multinational technology conglomerate. It is focused on industrial automation, building automation, rail transport and health technology. Siemens is the largest engineering company in Europe, and holds the position of global market leader in industrial automation and industrial software.
The origins of the conglomerate can be traced back to 1847 to the Telegraphen Bau-Anstalt von Siemens & Halske established in Berlin by Werner von Siemens and Johann Georg Halske. In 1966, the present-day corporation emerged from the merger of three companies: Siemens & Halske, Siemens-Schuckert, and Siemens-Reiniger-Werke. Today headquartered in Munich and Berlin, Siemens and its subsidiaries employ approximately 320,000 people worldwide and reported a global revenue of around €78 billion in 2023. The company is a component of the DAX and Euro Stoxx 50 stock market indices. As of December 2023, Siemens is the second largest German company by market capitalization.
Health technology in the context of Masimo
Masimo Corporation is an American health technology and consumer electronics company headquartered in Irvine, California. The company develops patient monitoring devices, non-invasive sensors, and related software platforms used in hospital and home settings. Masimo has also operated in the consumer audio and wearable device markets.
Health technology in the context of Heraeus
Heraeus is a German technology group with a focus on precious and special metals, medical technology, quartz glass and sensors as well as electronic components. Founded in Hanau in 1851, the company is one of the largest family-owned companies in Germany in terms of revenue. Heraeus employs 16,400 people in 40 countries and generated a total revenue of €25.6 billion in 2023. The headquarters and head office are in Hanau, Germany.
Health technology in the context of GE HealthCare
GE Healthcare Technologies, Inc. is an American health technology company based in Chicago, Illinois. The company, which stylizes its own name as GE HealthCare, operates four divisions: Medical imaging, which includes molecular imaging, computed tomography, magnetic resonance, women’s health screening and X-ray systems; Ultrasound; Patient Care Solutions, which is focused on remote patient monitoring, anesthesia and respiratory care, diagnostic cardiology, and infant care; and Pharmaceutical Diagnostics, which manufactures contrast agents and radiopharmaceuticals.
GE HealthCare's primary customers are hospitals and health networks. In 2023, the company received 42% of its revenue in the United States and 13% of its revenue from China, where the company faces increasing competition.