Guanajuato City in the context of Valenciana Mine

Guanajuato, officially the Free and Sovereign State of Guanajuato, is one of the 32 states that make up the Federal Entities of Mexico. It is divided into 46 municipalities and its capital city is Guanajuato.

It is located in central Mexico and is bordered by the states of Jalisco to the west, Zacatecas to the northwest, San Luis Potosí to the north, Querétaro to the east, and Michoacán to the south. It covers an area of 30,608 km (11,818 sq mi). The state is home to several historically important cities, especially those along the "Bicentennial Route", which retraces the path of Miguel Hidalgo y Costilla's insurgent army at the beginning of the Mexican War of Independence. This route begins at Dolores Hidalgo, and passes through the Sanctuary of Atotonilco, San Miguel de Allende, Celaya, and the capital of Guanajuato. Other important cities in the state include León, the state's biggest city, Salamanca, and Irapuato. The first town established by the Spaniards in Guanajuato is Acámbaro while the first to be named a city is Salvatierra.

San Miguel de Allende (Spanish pronunciation: [san miˈɣel de aˈʎende]) is the principal city in the municipality of San Miguel de Allende, located in the far eastern part of Guanajuato, Mexico. A part of the Bajío region, the town lies 274 km (170 mi) from Mexico City, 86 km (53 mi) from Querétaro and 97 km (60 mi) from the state capital of Guanajuato. The town's name derives from a 16th-century friar, Juan de San Miguel, and a martyr of Mexican Independence, Ignacio Allende, who was born in a house facing the central plaza. San Miguel de Allende was a critical epicenter during the historic Chichimeca War (1540–1590) when the Chichimeca held back the Spanish Empire during the initial phases of European colonization. Today, an old section of the town is part of a proclaimed World Heritage Site, attracting thousands of tourists and new residents from abroad every year.

At the beginning of the 20th century, the town was in danger of becoming a ghost town after an influenza pandemic. Gradually, its Baroque/Neoclassical colonial structures were "discovered" by foreign artists who moved in and began art and cultural institutes such as the Instituto Allende and the Escuela de Bellas Artes. This gave the town a reputation, attracting artists such as David Alfaro Siqueiros, who taught painting.

The Alhóndiga de Granaditas (Regional Museum of Guanajuato) (public grain exchange) is an old grain storage building in Guanajuato City, Mexico. This historic building was created to replace an old grain exchange near the city's river. The name Alhóndiga translates roughly from both Arabic and Spanish as grain market or warehouse. It is equivalent to the regional grain exchange. Its construction lasted from 1798 to 1809, by orders of Juan Antonio de Riaño y Bárcena, a Spaniard who was the quartermaster of the city during the Viceroyalty of New Spain. Miguel Hidalgo y Costilla and his insurgent army stormed the building during the first battle of the Mexican War of Independence, leading to the legend of el Pípila. The building received World Heritage listing as part of the Historic Town of Guanajuato in 1988.

The Guanajuato's River (Spanish: Rio Guanajuato) is a tributary of the Lerma River in the central near region of Mexico called the Bajio (Lowlands). The river begins in the silver-rich Guanajuato mountains near the state capital of Guanajuato City. The river is fed by the Guanajuato river basinca (in Spanish: cuenca) (a sub-basin to the much larger Lerma–Chapala Basin) and has an area of 3,320 km², which makes up approximately 10.32% of the total area of the state. There are approximately 900,000 people living in the Guanajuato River basin area, in the municipalities of Guanajuato, Irapuato, Romita, San Francisco del Rincon, Manuel Doblado and Pueblo Nuevo.