Grapefruit in the context of Barbados

Sulfur (American spelling and the preferred IUPAC name) or sulphur (Commonwealth spelling) is a chemical element; it has symbol S and atomic number 16. It is abundant, multivalent and nonmetallic. Under normal conditions, sulfur atoms form cyclic octatomic molecules with the chemical formula S₈. Elemental sulfur is a bright yellow, crystalline solid at room temperature.

Sulfur is the tenth most abundant element by mass in the universe and the fifth most common on Earth. Though sometimes found in pure, native form, sulfur on Earth usually occurs as sulfide and sulfate minerals. Being abundant in native form, sulfur was known in ancient times, being mentioned for its uses in ancient India, ancient Greece, China, and ancient Egypt. Historically and in literature sulfur is also called brimstone, which means "burning stone". Almost all elemental sulfur is produced as a byproduct of removing sulfur-containing contaminants from natural gas and petroleum. The greatest commercial use of the element is the production of sulfuric acid for sulfate and phosphate fertilizers, and other chemical processes. Sulfur is used in matches, insecticides, and fungicides. Many sulfur compounds are odoriferous, and the smells of odorized natural gas, skunk scent, bad breath, grapefruit, and garlic are due to organosulfur compounds. Hydrogen sulfide gives the characteristic odor to rotting eggs and other biological processes.

In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs.

Interactions may occur by simultaneous targeting of receptors, directly or indirectly. For example, both Zolpidem and alcohol affect GABA_A receptors, and their simultaneous consumption results in the overstimulation of the receptor, which can lead to loss of consciousness. When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used.

Eau de Cologne (French: [o d(ə) kɔlɔɲ]; German: Kölnisch Wasser [ˈkœlnɪʃ ˈvasɐ]; meaning "Water from Cologne") or simply cologne is a perfume originating in Cologne, Germany. Originally mixed by Johann Maria Farina (Giovanni Maria Farina) in 1709, it has since come to be a generic term for scented formulations in typical concentration of 2–5% and also more depending upon its type of essential oils or a blend of extracts, alcohol, and water. In a base of dilute ethanol (70–90%), eau de cologne contains a mixture of citrus oils, including oils of lemon, orange, tangerine, clementine, bergamot, lime, grapefruit, blood orange, bitter orange, and neroli. It can also contain oils of lavender, rosemary, thyme, oregano, petitgrain (orange leaf), jasmine, olive, oleaster, and tobacco.

In contemporary American English usage, the term "cologne" has become a generic term for perfumes marketed toward men. It also may signify a less concentrated, more affordable, version of a popular perfume.

The orange, also called sweet orange to distinguish it from the bitter orange (Citrus × aurantium), is the fruit of a tree in the family Rutaceae. Botanically, this is the hybrid Citrus × sinensis, between the pomelo (Citrus maxima) and the mandarin orange (Citrus reticulata). The chloroplast genome, and therefore the maternal line, is that of pomelo. Hybrids of the sweet orange form later types of mandarin and the grapefruit. The sweet orange has had its full genome sequenced.

The orange originated in a region encompassing Southern China, Northeast India, and Myanmar; the earliest mention of the sweet orange was in Chinese literature in 314 BC. Orange trees are widely grown in tropical and subtropical areas for their sweet fruit. The fruit of the orange tree can be eaten fresh or processed for its juice or fragrant peel. In 2022, 76 million tonnes of oranges were grown worldwide, with Brazil producing 22% of the total, followed by India and China.

Citrus is a genus of flowering trees and shrubs in the family Rutaceae. Plants in the genus produce citrus fruits, such as citrons, mandarins, and pomelos. Many important citrus crops have been developed through extensive hybridization, including oranges, lemons, grapefruits, and limes, all of which have many cultivars.

Citrus is native to South Asia, East Asia, Southeast Asia, Melanesia, and Australia. Indigenous people in these areas have used and domesticated various species since ancient times. Its cultivation first spread into Micronesia and Polynesia through the Austronesian expansion (c. 3000–1500 BCE). Later, it was spread to the Middle East and the Mediterranean (c. 1200 BCE) via the incense trade route, and then from Europe to the Americas.

Vanguard 1 (Harvard designation: 1958-Beta 2, COSPAR ID: 1958-002B) is an American satellite that was the fourth artificial Earth-orbiting satellite to be successfully launched, following Sputnik 1, Sputnik 2, and Explorer 1. It was launched 17 March 1958. Vanguard 1 was the first satellite to have solar electric power. Although communications with the satellite were lost in 1964, it remains the oldest artificial object still in orbit, together with the upper stage of its launch vehicle.

Vanguard 1 was designed to test the launch capabilities of a three-stage launch vehicle as a part of Project Vanguard, and the effects of the space environment on a satellite and its systems in Earth orbit. It also was used to obtain geodetic measurements through orbit analysis. Vanguard 1, being small and light enough to carry with one hand, was described by the Soviet Premier, Nikita Khrushchev, as "the grapefruit satellite".

The juice vesicles, also known as citrus kernels (in aggregate, citrus pulp), of a citrus fruit are the membranous content of the fruit's endocarp. The vesicles contain the juice of the fruit and appear shiny and saclike. Vesicles come in two shapes: the superior and inferior, and these are distinct. Citrus fruits with more vesicles generally weigh more than those with fewer vesicles. Fruits with many segments, such as the grapefruit or pomelo, have more vesicles per segment than fruits with fewer segments, such as the kumquat and mandarin. Each vesicle in a segment in citrus fruits has approximately the same shape, size, and weight. About 5% of the weight of an average orange is made up of the membranes of the juice vesicles.

Juice vesicles of the endocarp contain the components that provide the aroma typically associated with citrus fruit. These components are also found in the flavedo oil sacs. The vesicles and their inner juices contain many vitamins and minerals as well as the taste and sweet acid fragrance.

Sauvignon blanc (French pronunciation: [soviɲɔ̃ blɑ̃] ) is a green-skinned grape variety that most likely originated in the Loire Valley wine region in France, though it has also been historically cultivated in Bordeaux. The grape most likely gets its name from the French words sauvage ("wild") and blanc ("white") due to its early origins as an indigenous grape in South West France. It is possibly a descendant of Savagnin. Sauvignon blanc is planted in many of the world's wine regions, producing a crisp, dry, and refreshing white varietal wine. The grape is also a component of the famous dessert wines from Sauternes and Barsac. Sauvignon blanc is widely cultivated in France, Chile, Romania, Canada, Australia, New Zealand, South Africa, Bulgaria, the states of Oregon, Washington, and California in the US. Some New World Sauvignon blancs, particularly from California, may also be called "Fumé Blanc", a marketing term coined by Robert Mondavi in reference to Pouilly-Fumé.

Depending on the climate, the flavor can range from aggressively grassy to sweetly tropical. In cooler climates, the grape has a tendency to produce wines with noticeable acidity and "green flavors" of grass, green bell peppers and nettles with some tropical fruit (such as passion fruit) and floral (such as elderflower) notes. In warmer climates, it can develop more tropical fruit notes but risks losing much aroma from over-ripeness, leaving only slight grapefruit and tree fruit (such as peach) notes.

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits.

One whole grapefruit, or a small glass (200 mL, 6.8 US fl oz) of grapefruit juice, can cause drug overdose toxicity in patients taking felodipine. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying "Do not take with grapefruit" on the container, and the interaction is elaborated upon in the package insert. People are advised to ask their physician or pharmacist about drug interactions. However, some experts believe that for the majority of patients, complete avoidance of grapefruit is unwarranted.

The pomelo (/ˈpɒmɪloʊ, ˈpʌm-/ POM-il-oh, PUM-; or pummelo, Citrus maxima), also known as a shaddock, is the largest citrus fruit. It is an ancestor of several cultivated citrus species, including the bitter orange and the grapefruit. It is a natural, non-hybrid citrus fruit, native to Southeast Asia. Similar in taste to a sweet grapefruit, the pomelo is commonly eaten and used for festive occasions throughout Southeast and East Asia. As with the grapefruit, phytochemicals in the pomelo have the potential for drug interactions.

The Chelsea Physic Garden was established as the Apothecaries' Garden in London, England, in 1673 by the Worshipful Society of Apothecaries to grow plants to be used as medicines. This four-acre physic garden, the term here referring to the science of healing, is among the oldest botanical gardens in Britain, after the University of Oxford Botanic Garden. Its rock garden is the oldest in Europe devoted to alpine plants and Mediterranean plants. The garden has high brick walls which trap heat, giving it a warm micro-climate, and it claims the largest fruiting olive tree in Britain and the world's northernmost grapefruit growing outdoors. Jealously guarded during the tenure of the Worshipful Society of Apothecaries, the garden became a registered charity in 1983 and was opened to the general public for the first time.

The garden is a member of the London Museums of Health & Medicine. It is also Grade I listed in the Register of Historic Parks and Gardens of Special Historic Interest in England by English Heritage.