Giovanni Pico della Mirandola in the context of "Oration on the Dignity of Man"

The perennial philosophy (Latin: philosophia perennis), also referred to as perennialism and perennial wisdom, is a school of thought in philosophy and spirituality that posits that the recurrence of common themes across world religions illuminates universal truths about the nature of reality, humanity, ethics, and consciousness. Some perennialists emphasize common themes in religious experiences and mystical traditions across time and cultures; others argue that religious traditions share a single metaphysical truth or origin from which all esoteric and exoteric knowledge and doctrine have developed.

Perennialism has its roots in the Renaissance-era interest in neo-Platonism and its idea of the One from which all existence emerges. Marsilio Ficino (1433–1499) sought to integrate Hermeticism with Greek and Christian thought, discerning a prisca theologia found in all ages. Giovanni Pico della Mirandola (1463–1494) suggested that truth could be found in many—rather than just Biblical and Aristotelian traditions. He proposed a harmony between the thought of Plato and Aristotle and saw aspects of the prisca theologia in Averroes (Ibn Rushd), the Quran, Kabbalah, and other sources. Agostino Steuco (1497–1548) coined the term philosophia perennis.

Renaissance magic was a resurgence in Hermeticism and Neoplatonic varieties of the magical arts which arose along with Renaissance humanism in the 15th and 16th centuries CE. During the Renaissance period, magic and occult practices underwent significant changes that reflected shifts in cultural, intellectual, and religious perspectives. C. S. Lewis, in his work on English literature, highlighted the transformation in how magic was perceived and portrayed. In medieval stories, magic had a fantastical and fairy-like quality, while in the Renaissance, it became more complex and tied to the idea of hidden knowledge that could be explored through books and rituals. This change is evident in the works of authors like Spenser, Marlowe, Chapman, and Shakespeare, who treated magic as a serious and potentially dangerous pursuit.

Heinrich Cornelius Agrippa, a scholar, physician, and astrologer, popularized the Hermetic and Cabalistic magic of Marsilio Ficino and Giovanni Pico della Mirandola. Agrippa's ideas on magic were revolutionary, and he faced persecution for his criticism of authorities and ruling classes. His work, De occulta philosophia, explored both benevolent and malevolent magic, but he rejected forbidden forms of sorcery. Similarly, Paracelsus, a Swiss physician and alchemist, combined medical practice with astrology. He introduced elemental beings and viewed the cosmos as interconnected, assigning spiritual significance to natural elements.

Christian Kabbalah arose during the Renaissance due to Christian scholars' interest in the mysticism of Jewish Kabbalah, which they interpreted according to Christian theology. Often spelled Cabala to distinguish it from the Jewish form and from Hermetic Qabalah, it sought to link Kabbalistic concepts with Christian doctrines, particularly the Trinity. Early proponents included Giovanni Pico della Mirandola and Johann Reuchlin, who adapted Kabbalistic ideas to Christian beliefs, sometimes using them as a tool for conversion.

The movement drew from earlier Christian interest in Jewish mysticism, including the work of Spanish conversos and scholars like Ramon Llull, though it gained prominence in the 15th and 16th centuries. Christian Kabbalists proposed interpretations that linked Jesus and Mary to the Sefirot and saw hidden Christian messages in Kabbalistic texts. Figures such as Athanasius Kircher and Christian Knorr von Rosenroth further expanded these ideas, influencing later esoteric traditions.

San Marco is a Catholic religious complex in Florence, Italy. It comprises a church and a convent. The convent, which is now the Museo Nazionale di San Marco, has three claims to fame. During the 15th century it was home to two famous Dominicans, the painter Fra Angelico and the preacher Girolamo Savonarola. The church houses the relics of St Antoninus of Florence and the tomb of Pico Della Mirandola, a Renaissance philosopher known as the "Father of Humanism."