The Mongol conquest of Persia and Mesopotamia comprised three Mongol campaigns against Islamic states in the Middle East and Central Asia between 1219 and 1258. These campaigns led to the termination of the Khwarazmian Empire, the Nizari Ismaili state, and the Abbasid Caliphate of Baghdad, and the establishment of the Mongol Ilkhanate government in their place in Persia.
Genghis Khan had unified the Mongolic peoples and conquered the Western Xia state in the late 12th and early 13th centuries. After a series of diplomatic provocations on the part of Muhammad II, the ruler of the neighbouring Khwarazmian Empire, the Mongols launched an invasion in 1219. The invaders laid waste to the Transoxianan cities of Bukhara, Samarkand, and Gurganj in turn, before obliterating the region of Khorasan, slaughtering the inhabitants of Herat, Nishapur, and Merv, three of the largest cities in the world. Muhammad died destitute on an island in the Caspian Sea. His son and successor, Jalal al-Din, tried to resist the Mongols, but was defeated and forced into exile. Genghis returned to his campaign against the Jin dynasty in 1223, only retaining governance of the northern Khwarazmian regions.