Genetic chimerism in the context of "Human chimera"

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⭐ Core Definition: Genetic chimerism

A genetic chimerism or chimera (/kˈmɪərə, kɪ-/ ky-MEER-ə, kih-) is a single organism composed of cells of different genotypes. Animal chimeras can be produced by the fusion of two (or more) embryos. In plants and some animal chimeras, mosaicism involvesdistinct types of tissue that originated from the same zygote, but differ due to mutation during ordinary cell division.

Normally, genetic chimerism is not visible on casual inspection; however, it has been detected in the course of proving parentage. More practically, in agronomy, "chimera" indicates a plant or portion of a plant whose tissues are made up of two or more types of cells with different genetic makeup; it can derive from a bud mutation or, more rarely, at the grafting point, from the concrescence of cells of the two bionts; in this case it is commonly referred to as a "graft hybrid", although it is not a hybrid in the genetic sense of "hybrid".

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👉 Genetic chimerism in the context of Human chimera

A human chimera is a human with a subset of cells with a distinct genotype than other cells, that is, having genetic chimerism. An organism that contains a mixture of human and non-human cells would be a human–animal chimera.

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Genetic chimerism in the context of Sport (botany)

In botany, a sport or bud sport, traditionally called lusus, is a part of a plant that shows morphological differences from the rest of the plant. Sports may differ by foliage shape or color, flowers, fruit, or branch structure. The cause is generally thought to be chance genetic mutations in a single cell. Sports may also arise from stable changes in gene expression due to epigenetic modifications, including histone modification, DNA methylation, chromatin remodeling and RNA silencing. If the clonal descendants of a modified cell eventually form a meristem that gives rise to new plant parts, those may be of a new phenotype. Often only part of the meristem cells are affected, resulting in genetic chimerism in such sports.

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