Frequency ratio in the context of "Middle C"

Pythagorean tuning is a system of musical tuning in which the frequency ratios of all intervals are determined by choosing a sequence of fifths which are "pure" or perfect, with ratio ${\displaystyle 3:2}$. This is chosen because it is the next harmonic of a vibrating string, after the octave (which is the ratio ${\displaystyle 2:1}$), and hence is the next most consonant "pure" interval, and the easiest to tune by ear. As Novalis put it, "The musical proportions seem to me to be particularly correct natural proportions." Alternatively, it can be described as the tuning of the syntonic temperament in which the generator is the ratio 3:2 (i.e., the untempered perfect fifth), which is ≈ 702 cents wide.

The system dates back to Ancient Mesopotamia;. (See Music of Mesopotamia § Music theory.) It is named, and has been widely misattributed, to Ancient Greeks, notably Pythagoras (sixth century BC) by modern authors of music theory. Ptolemy, and later Boethius, ascribed the division of the tetrachord by only two intervals, called "semitonium" and "tonus" in Latin (256:243 × 9:8 × 9:8), to Eratosthenes. The so-called "Pythagorean tuning" was used by musicians up to the beginning of the 16th century. "The Pythagorean system would appear to be ideal because of the purity of the fifths, but some consider other intervals, particularly the major third, to be so badly out of tune that major chords [may be considered] a dissonance."