The First Secretary of the Central Committee of the Communist Party of Ukraine (Ukrainian: Перший Секретар ЦК КПУ, romanized: Pershyi Sekretar TsK KPU, Russian: Первый Секретарь ЦК КПУ) was a party leader of the republican branch of the Communist Party of the Soviet Union. The office's name alternated throughout its history between First Secretary and the General Secretary.
The secretary was the de facto leader of the Ukrainian Soviet Socialist Republic through Article 6 of the Soviet Constitution, which made the Communist Party of the Soviet Union the "leading and guiding force of the Soviet society". These powers were revoked with the revision to Article 6 on 24 October 1990 that removed the Communist Party's monopoly on power.