Eric Foreman in the context of "David Shore"

House (also known as House, M.D.) is an American medical drama television series created by David Shore that originally aired on Fox from November 16, 2004, to May 21, 2012, for eight seasons. It features the life of Dr. Gregory House (Hugh Laurie), an unconventional, misanthropic, cynical medical genius who, despite his dependence on pain medication, successfully leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey. House often clashes with his fellow physicians, including his own diagnostic team, because many of his hypotheses about patients' illnesses are based on subtle or controversial insights, and his flouting of hospital rules and procedures frequently leads him into conflict with his boss, hospital administrator and Dean of Medicine Dr. Lisa Cuddy (Lisa Edelstein). House's only true friend is Dr. James Wilson (Robert Sean Leonard), head of the Department of Oncology.

During the first three seasons, House's diagnostic team consists of Dr. Robert Chase (Jesse Spencer), Dr. Allison Cameron (Jennifer Morrison), and Dr. Eric Foreman (Omar Epps). At the end of the third season, this team disbands. Rejoined by Foreman, House gradually selects three new team members: Dr. Remy "Thirteen" Hadley (Olivia Wilde), Dr. Chris Taub (Peter Jacobson), and Dr. Lawrence Kutner (Kal Penn). Chase and Cameron continue to appear occasionally in different roles at the hospital. Kutner dies late in season five; early in season six, Cameron departs the hospital, and Chase returns to the diagnostic team. Thirteen takes a leave of absence for most of season seven, and her position is filled by medical student Martha M. Masters (Amber Tamblyn). Cuddy and Masters depart before season eight; Foreman becomes the new Dean of Medicine, while Dr. Jessica Adams (Odette Annable) and Dr. Chi Park (Lo Mutuc, credited as Charlyne Yi) join House's team.

Omar Hashim Epps (born July 20, 1973) is an American actor, rapper, and producer. Epps's film roles include Juice, Higher Learning, The Wood, In Too Deep, and Love & Basketball. His television work includes the role of Dr. Dennis Gant on the medical drama series ER, J. Martin Bellamy in Resurrection, Dr. Eric Foreman on the Fox medical drama series House from 2004 to 2012, Isaac Johnson in the TV series Shooter from 2016 to 2018, and Detective Malcolm Howard on the Starz crime drama Power Book III: Raising Kanan. He has been awarded nine NAACP Image Awards, two Teen Choice Awards, one MTV Movie Award, one Black Reel Award, and one Screen Actors Guild Award.

Remy "Thirteen" Hadley, M.D., is a fictional character on the medical drama House, portrayed by Olivia Wilde. She is part of the new diagnostic team assembled by Dr. Gregory House after the disbanding of his previous team in the third-season finale. The character's nickname derives from the episode "The Right Stuff", when she is assigned the number during a competition for her position at the Princeton-Plainsboro Teaching Hospital.

The show depicts Thirteen as a secretive character who does not divulge personal information; her surname was not used on the show until the fourth season's penultimate episode "House's Head", nor her given name until the fifth-season episode "Emancipation". Instead, several of the character's traits are implied before they are depicted as true. In the season four episode "You Don't Want to Know", Thirteen tells House that her mother died from Huntington's disease; a test she performs several episodes later confirms she carries the gene. After hints were given regarding her character's sexuality, Wilde confirmed that her character is indeed bisexual. This is confirmed by Eric Foreman in the episode "Don't Ever Change".