Egypt–Mesopotamia relations were the relations between the civilizations of ancient Egypt and Mesopotamia, in the Middle East. They seem to have developed from the 4th millennium BCE, starting in the Uruk period for Mesopotamia (circa 4000–3100 BCE) and the half a millennium younger Gerzean culture of Prehistoric Egypt (circa 3500–3200 BCE), and constituted a largely one way body of influences from Mesopotamia into Egypt.
Prior to a specific Mesopotamian influence there had already been a longstanding influence from West Asia into Egypt, North Africa and even into some parts of the Horn of Africa and the Sahel in the form of the Neolithic Revolution which from circa 9000 BCE diffused advanced agricultural practices and technology, gene-flow, certain domesticated animals and crops and the likely spread of Proto-Afroasiatic language into the region, with Semitic languages that had evolved in West Asia circa 4000 BCE being introduced via the Arabian Peninsula and Levant into the Horn of Africa and North Africa respectively after 1000 BCE.
