Edict of Thessalonica in the context of "Theodosian code"

The Edict of Milan (Latin: Edictum Mediolanense; Greek: Διάταγμα τῶν Μεδιολάνων, Diatagma tōn Mediolanōn) was the February 313 agreement to treat Christians benevolently within the Roman Empire. Western Roman Emperor Constantine I and Emperor Licinius, who controlled the Balkans, met in Mediolanum (modern-day Milan) and, among other things, agreed to change policies towards Christians following the edict of toleration issued by Emperor Galerius two years earlier in Serdica. The Edict of Milan gave Christianity legal status and a reprieve from persecution but did not make it the state church of the Roman Empire, which occurred in AD 380 with the Edict of Thessalonica, when Nicene Christianity received normative status.

The document is found in Lactantius's De mortibus persecutorum and in Eusebius of Caesarea's History of the Church with marked divergences between the two. Whether or not there was a formal 'Edict of Milan'  is no longer really debated among scholars, who generally reject the story as it has come down in church history.

Early Christians were heavily persecuted throughout the Roman Empire until the 3rd century. Although Christianity initially emerged as a small Jewish movement in 1st-century Judaea, it quickly branched off as a separate religion and began spreading across the various Roman territories at a pace that put it at odds with the well-established Roman imperial cult, to which it stood in opposition; Christians were vocal in their expressions of abhorrence towards the beliefs and practices of Roman paganism, such as deifying and making ritual sacrifices to the Roman emperor or partaking in other methods of idolatry. Consequently, the Roman state and other members of civic society routinely punished Christians for treason, various rumoured crimes, illegal assembly, and for introducing an alien cult that drove many Roman people to apostasy in favour of Jesus Christ. According to Tacitus, the first wave of organized persecution occurred under Nero (r. 54–68), who blamed Christians for the Great Fire of Rome in 64. A number of mostly localized persecutions occurred during the reign of Marcus Aurelius (r. 161–180). After a lull, persecution resumed under Decius (r. 249–251) and Trebonianus Gallus (r. 251–253). The Decian persecution was particularly extensive, as Decius strived to restore the Roman golden age in part by forcing pagan practices upon the Christian community. Another wave of persecution began under Valerian (r. 253–260), but ceased abruptly after he was captured and taken prisoner by the Sasanian Empire during the Battle of Edessa of the Roman–Persian Wars. Under his successor Gallienus (r. 253–268), whose reign was marred by rapidly escalating military conflicts of the Crisis of the Third Century, the first ever decree of tolerance was issued for Christian practices and places of worship, although it stopped short of recognizing Christianity as a religion with legal status.

Emperor Diocletian (r. 283–305) began the Diocletianic persecution, which was the final and the most severe wave of persecution of Christians by the Roman state. It was enforced until the accession of Galerius (r. 305–311), who issued the Edict of Serdica, and the death of Maximinus Daza (r. 310–313). After Constantine the Great (r. 306–337) defeated his rival Maxentius (r. 306–312) at the Battle of the Milvian Bridge in October 312, he and his co-emperor Licinius issued the Edict of Milan, which decriminalized Christianity and suppressed pagan populations throughout the Roman Empire. In 380, Theodosius I (r. 379–395) issued the Edict of Thessalonica, officially establishing Christianity as the Roman state religion. It was also during the reign of Theodosius I that pagan practices were overtly deemed punishable offenses, which laid the framework for early Byzantine anti-pagan policies.

Gratian (/ˈɡreɪʃiən/; Latin: Gratianus; 18 April 359 – 25 August 383) was emperor of the Western Roman Empire from 367 to 383. The eldest son of Valentinian I, Gratian was raised to the rank of Augustus as a child and inherited the West after his father's death in 375. He nominally shared the government with his infant half-brother Valentinian II, who was also acclaimed emperor in Pannonia on Valentinian's death. The East was ruled by his uncle Valens, who was later succeeded by Theodosius I.

Gratian subsequently led a campaign across the Rhine, attacked the Lentienses, and forced the tribe to surrender. That same year, the eastern emperor Valens was killed fighting the Goths at the Battle of Adrianople, which led to Gratian elevating Theodosius to replace him in 379. Gratian favoured Nicene Christianity over traditional Roman religion, issuing the Edict of Thessalonica, refusing the office of pontifex maximus, and removing the Altar of Victory from the Roman Senate's Curia Julia. The city of Cularo on the Isère river in Roman Gaul was renamed Gratianopolis after him, which later evolved to Grenoble. By 383 Gratian had become unpopular with his army, which abandoned him during a confrontation with the usurper Magnus Maximus near Lutetia (Paris). Gratian fled to Lugdunum and was later murdered.

In the year before the First Council of Constantinople in 381, Nicene Christianity became the official religion of the Roman Empire when Theodosius I, emperor of the East, Gratian, emperor of the West, and Gratian's junior co-ruler Valentinian II issued the Edict of Thessalonica in 380, which recognized the catholic orthodoxy, as defined by the Council of Nicea, as the Roman Empire's state religion. Historians refer to this state-sponsored church using a variety of terms: the catholic church, the orthodox church, the imperial church, the Roman church, or the Byzantine church, with some also used for wider communions extending beyond the Roman Empire. The Eastern Orthodox Church, Oriental Orthodoxy, and the Catholic Church all claim to stand in continuity from the Nicene Christian church to which Theodosius granted recognition. Political differences between the Eastern Roman Empire and the Persian Sassanid Empire led to the separation of the Church of the East in 424. A doctrinal split within the imperial church led to the independence of early Oriental Orthodoxy, while the fall of the Western Roman Empire initiated the gradual separation between Eastern and Western Christianity, culminating in the East-West schism of 1054. The Western Church evolved into the Latin Catholic Church while the Eastern Church that remained under the patronage of the Eastern empire and evolved into the Greek Orthodox Church.

Earlier in the 4th century, following the Diocletianic Persecution of 303–313 and the Donatist controversy that arose in consequence, Constantine the Great had convened councils of bishops to define the orthodoxy of the Christian faith and to expand on earlier Christian councils. A series of ecumenical councils convened by successive Roman emperors met during the 4th and the 5th centuries, but Christianity continued to suffer rifts and schisms surrounding the theological and christological doctrines of Arianism, Nestorianism, Miaphysitism, and Dyophysitism. In the 5th century, the Western Roman Empire decayed as a polity; invaders sacked Rome in 410 and in 455, and Odoacer, an Arian barbarian warlord, forced Romulus Augustus, the last nominal Western Emperor, to abdicate in 476. However, apart from the aforementioned schisms, the church as an institution persisted in communion, if not without tension, between the East and West. In the 6th century, the Byzantine armies of the Byzantine Emperor Justinian I recovered Italy and other regions of the Western Mediterranean shore. The Byzantine Empire soon lost most of these gains, but it held Rome, as part of the Exarchate of Ravenna, until 751, a period known in church history as the Byzantine Papacy. The early Muslim conquests of the 7th–9th centuries would begin a process of converting most of the then-Christian world in the Levant, Middle East, North Africa, regions of Southern Italy and the Iberian Peninsula to Islam, severely restricting the reach both of the Byzantine Empire and of its church. Christian missionary activity directed from the capital of Constantinople did not lead to a lasting expansion of the formal link between the church and the Byzantine emperor, since areas outside the Byzantine Empire's political and military control set up their own distinct churches, as in the case of Bulgaria in 919.

Christianity in the 4th century was dominated in its early stage by Constantine the Great and the First Council of Nicaea of 325, which was the beginning of the period of the First seven Ecumenical Councils (325–787), and in its late stage by the Edict of Thessalonica of 380, which made Nicene Christianity the state church of the Roman Empire.

Valentinianism was one of the major Gnostic Christian movements. Founded by Valentinus (b. c. 100 CE – d. c. 165 CE) in the 2nd century, its influence spread widely, not just within the Roman Empire but also from northwest Africa to Egypt through to Asia Minor and Syria in the east. Later in the movement's history, it broke into Eastern and a Western schools. The Valentinian movement remained active until the 4th century, declining after Emperor Theodosius I issued the Edict of Thessalonica in 380, which established Nicene Christianity as the state religion of the Roman Empire.

No evidence exists that Valentinus was labeled a heretic during his lifetime. Irenaeus of Lyons, who was the first patristic source to describe Valentinus's teachings—though likely incompletely and with a bias toward the time's proto-orthodox Christianity—did not finish his apologetic work Against Heresies until the latter 2nd century, likely sometime after Valentinus's death. The rapid growth of the Valentinian Gnostic movement—named eponymously after Valentinus—after his death prompted early Christian thought leaders, such as Irenaeus and later Hippolytus of Rome, to write apologetic works against Valentinus and Valentinianism, which conflicted with proto-orthodox theology. Because the proto-orthodox camp's leadership encouraged the destruction of Gnostic texts writ large, most textual evidence regarding Valentinian theology and practice comes from its critics—particularly Irenaeus, who was highly focused on refuting Valentinianism.

Christianity in late antiquity traces Christianity during the Christian Roman Empire — the period from the rise of Christianity under Emperor Constantine (c. 313), until the fall of the Western Roman Empire (c. 476). The end-date of this period varies because the transition to the sub-Roman period occurred gradually and at different times in different areas. One may generally date late ancient Christianity as lasting to the late 6th century and the re-conquests under Justinian (reigned 527–565) of the Byzantine Empire, though a more traditional end-date is 476, the year in which Odoacer deposed Romulus Augustus, traditionally considered the last western emperor.

Christianity began to spread initially from Roman Judaea without state support or endorsement. It became the state religion of Armenia in either 301 or 314, of Ethiopia in 325, and of Georgia in 337. With the Edict of Thessalonica it became the state religion of the Roman Empire in 380.