Eastmain (Quebec French pronunciation: [iːstˈmẽɪ̯̃]; Cree: ᐄᔅᒣᐃᓐ/Îsmein) is a Cree community located on the east coast of James Bay at the mouth of the Eastmain River, Quebec, Canada. It is a small coastal Cree village with a population of 924 people in the 2021 Canadian Census up from 866 people at the 2016 Canadian Census. Its alternate Cree name is ᐙᐸᓅᑖᐤ/Wâpanûtâw, meaning Lands east of James Bay.
Eastmain is accessible by air (Eastmain River Airport) and by car over a gravel road linking it to the James Bay Road, which takes around 1 hour.