Eastern Anatolia in the context of "Van Province"

The Armenian highlands (Armenian: Հայկական լեռնաշխարհ, romanized: Haykakan leṙnašxarh; also known as the Eastern Anatolian highlands, Armenian upland, Armenian plateau, or Armenian tableland) comprise the most central and the highest of the three plateaus that together form the northern sector of West Asia. Clockwise starting from the west, the Armenian highlands are bounded by the Anatolian plateau, the Caucasus, the Kura-Aras lowlands, the Iranian Plateau, and Mesopotamia. The highlands are divided into western and eastern regions, defined by the Ararat Valley where Mount Ararat is located. Since the turn of the 20th century, Western Armenia has been relabeled as "Eastern Anatolia" by Ottoman and Turkish authorities. Eastern Armenia is part of Lesser Caucasus, which was historically known by some as the Anti-Caucasus, meaning "opposite of the Caucasus".

During the Iron Age, the region was known by variations of the name Ararat (Urartu, Uruatri, Urashtu). Later, the Highlands were known as Armenia Major, a central region to the history of Armenians, and one of the four geopolitical regions associated with Armenians, the other three being Armenia Minor, Sophene, and Commagene. The highlands are primarily defined by the geographical dispersal of its native inhabitants, the Armenians. Prior to the appearance of nominally Armenian people in historical records, historians have hypothesized that the region must have been home to various ethnic groups who became homogenous when the Armenian language came to prominence. The population of the Armenian highlands has had a high level of regional genetic continuity for over 6,000 years. Recent studies indicate that the Armenian people descend from the indigenous people of the Armenian highlands and form a distinct genetic isolate in the region. The region was also inhabited during Antiquity by minorities such as Assyrians, Georgians, Greeks, Jews, and Iranians. During the Middle Ages, Arabs and particularly Turkmens and Kurds settled in large numbers in the Armenian highlands.

Greeks have been present in what is now southern Russia from the 6th century BC; those settlers assimilated into the indigenous populations. The vast majority of contemporary Russia's Greek minority populations are descendants of Medieval Greek refugees, traders, and immigrants (including farmers, miners, soldiers, and churchmen/bureaucrats) from the Byzantine Empire, the Ottoman Balkans, and Pontic Greeks from the Empire of Trebizond and Eastern Anatolia who settled mainly in southern Russia and the South Caucasus in several waves between the mid-15th century and the second Russo-Turkish War of 1828–29. As during the Genocide of the Pontic Greeks, the survivors fled to the Upper Pontus (in the USSR).

In former Soviet republics, about 70% are Greek speakers who are mainly descendants of Pontic Greeks from the Pontic Alps region of northeast Anatolia, 29% are Turkish-speaking Greeks (Urums) from Tsalka in Georgia, and 1% are Greek speakers from Mariupol in Ukraine.

The House of Mengüjek (Modern Turkish: Mengüçoğulları, Mengücek Beyliği or Mengüçlü Beyliği; the reigning dynasty is known as Mengujekids or Menkujakids) was a Turkish Anatolian beylik (principality) of the first period, founded after the Battle of Manzikert. The Mengujekids ruled the regions of Erzincan, Kemah, Şebinkarahisar and Divriği in Eastern Anatolia in the 12th and 13th centuries.

The history of Armenia covers the topics related to the history of the Republic of Armenia, as well as the Armenian people, the Armenian language, and the regions of Eurasia historically and geographically considered Armenian.

Armenia is located between Eastern Anatolia and the Armenian highlands, surrounding the Biblical mountains of Ararat. The endonym of the Armenians is hay, and the old Armenian name for the country is Hayk' (Armenian: Հայք, which also means "Armenians" in Classical Armenian), later Hayastan (Armenian: Հայաստան). Armenians traditionally associate this name with the legendary progenitor of the Armenian people, Hayk. The names Armenia and Armenian are exonyms, first attested in the Behistun Inscription of Darius the Great. The early Armenian historian Movses Khorenatsi derived the name Armenia from Aramaneak, the eldest son of the legendary Hayk. Various theories exist about the origin of the endonym and exonyms of Armenia and Armenians (see Name of Armenia).

Malatya (Turkish pronunciation: [mɑɫɑtjɑ]; Armenian: Մալաթիա, romanized: Malat'ia; Syriac ܡܠܝܛܝܢܐ Malīṭīná; Ancient Greek: Μελιτηνή) is a city in the Eastern Anatolia region of Turkey and the capital of Malatya Province. The city has been a human settlement for thousands of years.

In Hittite, melid or milit means 'honey', offering a possible etymology for the name, which was mentioned in the contemporary sources of the time under several variations (e.g., Hittite: Malidiya and possibly also Midduwa; Akkadian: Meliddu; Urar̩tian: Meliṭeia). Strabo says that the city was known "to the ancients" as Melitene (Ancient Greek Μελιτηνή), a name adopted by the Romans following Roman expansion into the east. According to Strabo, the inhabitants of Melitene shared the language and culture of the nearby Cappadocians and Cataonians.