East Side (Manhattan) in the context of "First Avenue (Manhattan)"

The economy of New York City encompasses the largest municipal and regional economy in the United States. In 2023, the New York City Metropolitan Area generated a GMP of US$2.299 trillion. Anchored by Wall Street in Lower Manhattan, New York City has been characterized as the world's premier fintech and financial center. The city is home to the New York Stock Exchange (NYSE, on Wall Street) and Nasdaq (headquartered in Times Square), the world's two largest stock exchanges by both market capitalization and trading activity.

New York City, with its center in Manhattan, is the world's leading center of banking, finance, and communication. Many of the world's largest corporations are headquartered in Manhattan. The borough contained over 500 million square feet (46.5 million m) of office space in 2015, making it the largest office market in the United States. Midtown Manhattan, with nearly 400 million square feet (37.2 million m) that same year, is the largest central business district in the world. New York City is distinctive for its high concentrations of advanced service sector firms in the law, accountancy, banking, and management consultancy fields. It is the top global center for the advertising industry, which is metonymously called "Madison Avenue". Silicon Alley, metonymous for New York's broad-spectrum high technology sphere, continues to expand.

42nd Street is a major crosstown street in the New York City borough of Manhattan, spanning the entire breadth of Midtown Manhattan, from Turtle Bay at the East River, to Hell's Kitchen at the Hudson River on the West Side. The street has several major landmarks, including (from east to west) the headquarters of the United Nations, the Chrysler Building, Grand Central Terminal, the New York Public Library Main Branch, Times Square, and the Port Authority Bus Terminal.

The street is known for its theaters, especially near the intersection with Broadway at Times Square, and as such is also the name of the region of the theater district (and, at times, the red-light district) near that intersection. The street also has a section of off-Broadway theaters known as Theatre Row.

14th Street is a major crosstown street in the New York City borough of Manhattan, traveling between Eleventh Avenue on Manhattan's West Side and Avenue C on Manhattan's East Side. It forms a boundary between several neighborhoods and is sometimes considered the border between Lower Manhattan and Midtown Manhattan.

At Broadway, 14th Street forms the southern boundary of Union Square. It is also considered the southern boundary of Chelsea, Flatiron/Lower Midtown, and Gramercy, and the northern boundary of Greenwich Village, Alphabet City, and the East Village. West of Third Avenue, 14th Street marks the southern terminus of western Manhattan's grid system. North of 14th Street, the streets make up a near-perfect grid that runs in numerical order. South of 14th, the grid continues in the East Village almost perfectly, except in Greenwich Village, where an older and less uniform grid plan applies.

59th Street is a crosstown street in the New York City borough of Manhattan, running from York Avenue and Sutton Place on the East Side of Manhattan to the West Side Highway on the West Side. The three-block portion between Columbus Circle and Grand Army Plaza is also known as Central Park South, since it forms the southern border of Central Park. There is a gap in the street between Ninth Avenue/Columbus Avenue and Columbus Circle, where the Deutsche Bank Center is located. While the Central Park South section is a bidirectional street, most of 59th Street carries one-way traffic.

59th Street forms the border between Midtown Manhattan and Upper Manhattan. North of 59th Street, the neighborhoods of the Upper West Side and Upper East Side continue on either side of Central Park. On the West Side, Manhattan's numbered avenues are renamed north of 59th Street: Eighth Avenue (at Columbus Circle) becomes Central Park West; Ninth Avenue is renamed Columbus Avenue; Tenth Avenue is renamed Amsterdam Avenue; and Eleventh Avenue becomes West End Avenue.

Houston Street (/ˈhaʊstən/ HOW-stən) is a major east–west thoroughfare in Lower Manhattan in New York City, New York. It runs the full width of the island of Manhattan, from FDR Drive along the East River in the east to the West Side Highway along the Hudson River in the west. The street is divided into west and east sections by Broadway.

Houston Street generally serves as the boundary between neighborhoods on the East Side of Manhattan—Alphabet City, the East Village, NoHo, Greenwich Village, and the West Village to the north; and the Lower East Side, most of the Bowery, Nolita, and SoHo to the south. The numeric street-naming grid in Manhattan, created as part of the Commissioners' Plan of 1811, begins immediately north of Houston Street with 1st Street at Avenue A.

Murray Hill is a neighborhood on the east side of Manhattan in New York City. Murray Hill is generally bordered to the east by the East River or Kips Bay and to the west by Midtown Manhattan, though the exact boundaries are disputed. Murray Hill is situated on a steep glacial hill that peaked between Lexington Avenue and Broadway. It was named after Robert Murray, the head of the Murray family, a mercantile family that settled in the area in the 18th century.

The Murray farm was formed before 1762 and existed until at least the early 19th century. Through the 19th century, Murray Hill was relatively isolated from the rest of New York City, which at the time was centered in Lower Manhattan. Murray Hill became an upscale neighborhood during the 20th century. Today, it contains several cultural institutions such as the Morgan Library & Museum, as well as missions and consulates to the nearby United Nations headquarters. The neighborhood also contains architectural landmarks, some of which are in the Murray Hill Historic District, a city and national historic district.

York Avenue, Sutton Place, and Sutton Place South are the names of segments of a north–south thoroughfare in the Yorkville, Lenox Hill, and Sutton Place neighborhoods of the East Side of Manhattan, in New York City. York Avenue runs from 59th to 92nd Streets through eastern Lenox Hill and Yorkville on the Upper East Side. Sutton Place and Sutton Place South run through their namesake neighborhood along the East River and south of the Queensboro Bridge. Sutton Place South runs from 57th to 53rd Streets. Unlike most north–south streets in Manhattan, building address numbers along Sutton Place South increase when headed south. Sutton Place runs from 57th to 59th Streets. The streets are considered among the city's most affluent, and both portions are known for upscale apartments, much like the rest of the Upper East Side.

Addresses on York Avenue are continuous with that of Avenue A in the Alphabet City neighborhood, starting in the 1100 series and rising to the 1700 series. Addresses on Sutton Place and Sutton Place South do not follow the usual pattern in Manhattan.