Durlach in the context of "Charles II, Margrave of Baden-Durlach"

Karlsruhe (/ˈkɑːrlzruːə/ KARLZ-roo-ə; US also /ˈkɑːrls-/ KARLSS-; German: [ˈkaʁlsˌʁuːə] ; South Franconian: Kallsruh) is the third-largest city of the German state of Baden-Württemberg, after its capital Stuttgart and Mannheim, and the 22nd-largest city in the nation, with 308,436 inhabitants. It is also a former capital of Baden, a historic region named after Hohenbaden Castle in the city of Baden-Baden. Located on the right bank of the Rhine (Upper Rhine) near the French border, between the Mannheim-Ludwigshafen conurbation to the north and Strasbourg to the south, Karlsruhe is Germany's legal center, being home to the Federal Constitutional Court, the Federal Court of Justice and the Public Prosecutor General.

Karlsruhe was the capital of the Margraviate of Baden-Durlach (Durlach: 1565–1718; Karlsruhe: 1718–1771), the Margraviate of Baden (1771–1803), the Electorate of Baden (1803–1806), the Grand Duchy of Baden (1806–1918), and the Republic of Baden (1918–1945). Its most remarkable building is Karlsruhe Palace, which was built in 1715. It contains the Baden State Museum, the large cultural, art and regional history museum of the Baden region of Baden-Württemberg. There are nine institutions of higher education in the city, most notably the Karlsruhe Institute of Technology. Karlsruhe/Baden-Baden Airport is the second-busiest airport in Baden-Württemberg after Stuttgart Airport, and the 17th-busiest airport in Germany.

The Margraviate of Baden-Durlach was an early modern territory of the Holy Roman Empire, in the upper Rhine valley, which existed from 1535 to 1771. It was formed when the Margraviate of Baden was split between the sons of Margrave Christopher I and was named for its capital, Durlach. The other half of the territory became the Margraviate of Baden-Baden, located between the two halves of Baden-Durlach. Baden-Durlach became Lutheran during the Protestant Reformation, unlike Baden-Baden, which remained Catholic. Baden-Durlach occupied Baden-Baden from 1594 to 1622, but was driven out after being defeated at the Battle of Wimpfen, during the Thirty Years' War (1618–1648). The territory was ravaged during the Nine Years' War (1688–1697). Following the extinction of the Baden-Baden line in 1771, the Baden-Durlach inherited their territories and reunited the Margraviate of Baden. The reunified territory was caught up in the French Revolutionary and Napoleonic Wars, emerging in 1806 as the Grand Duchy of Baden.

Karlsruhe Palace (German: Karlsruher Schloss) was built in 1715 for Margrave Charles III William of Baden-Durlach after a dispute with the citizens of his previous capital, Durlach. The city of Karlsruhe has since grown around it. The building is now home to the main museum of the Badisches Landesmuseum.