Dukkha in the context of "Wisdom in Buddhism"

Nirvana or nibbana (Sanskrit: निर्वाण; IAST: nirvāṇa; Pali: nibbāna) is the extinguishing of the passions, the "blowing out" or "quenching" of the activity of the grasping mind and its related suffering, stresses, and unease. Nirvana is the goal of many Buddhist paths, and leads to the soteriological release from dukkha ('suffering') and rebirths in saṃsāra. Nirvana is part of the Third Truth on "cessation of dukkha" in the Four Noble Truths, and the "summum bonum of Buddhism and goal of the Eightfold Path."

In all forms of Buddhism, Nirvana is regarded as the highest or supreme religious goal. It is often described as the unconditioned or uncompounded (Skt.: asaṃskṛta, Pali: asankhata), meaning it is beyond all forms of conditionality — not subject to change, decay, or the limitations of time and space. Nirvana is typically seen as being outside the realm of dependent arising (pratītyasamutpāda), representing a truth that transcends cause and effect, as well as all conventional dualities such as existence and non-existence, or life and death. Nirvana is also said to transcend all conceptual frameworks, being beyond the grasp of ordinary human perception.

Upādāna (Hindi: उपादान) is a Sanskrit and Pali word that means "fuel, material cause, substrate that is the source and means for keeping an active process energized". It is also an important Buddhist concept referring to "attachment, clinging, grasping". It is considered to be the result of taṇhā (craving), and is part of the duhkha (dissatisfaction, suffering, pain) doctrine in Buddhism.

In Buddhism, the Four Noble Truths (Sanskrit: चत्वार्यार्यसत्यान, romanized: catvāryāryasatyāni; Pali: cattāri ariyasaccāni; "The Four arya satya") are "the truths of the noble one (the Buddha)," a statement of how things really are when they are seen correctly. The four truths are

• dukkha (not being at ease, 'suffering', from dush-stha, standing unstable). Dukkha is an innate characteristic of transient existence; nothing is forever, this is painful;
• samudaya (origin, arising, combination; 'cause'): together with this transient world and its pain, there is also thirst (desire, longing, craving) for and attachment to this transient, unsatisfactory existence;
• nirodha (cessation, ending, confinement): the attachment to this transient world and its pain can be severed or contained by the confinement or letting go of this craving;
• marga (road, path, way): the Noble Eightfold Path is the path leading to the confinement of this desire and attachment, and the release from dukkha.

The four truths appear in many grammatical forms in the ancient Buddhist texts, and are traditionally identified as the first teaching given by the Buddha. While often called one of the most important teachings in Buddhism, they have both a symbolic and a propositional function. Symbolically, they represent the awakening and liberation of the Buddha, and of the potential for his followers to reach the same liberation and freedom that he did. As propositions, the Four Truths are a conceptual framework that appear in the Pali canon and early Hybrid Sanskrit Buddhist scriptures, as a part of the broader "network of teachings" (the "dhamma matrix"), which have to be taken together. They provide a conceptual framework for introducing and explaining Buddhist thought, which has to be personally understood or "experienced".

Pratītyasamutpāda (Sanskrit: प्रतीत्यसमुत्पाद, Pāli: paṭiccasamuppāda), commonly translated as dependent origination, or dependent arising, is a key doctrine in Buddhism shared by all schools of Buddhism. It states that all dharmas (phenomena) arise in dependence upon other dharmas: "if this exists, that exists; if this ceases to exist, that also ceases to exist". The basic principle is that all things (dharmas, phenomena, principles) arise in dependence upon other things.

The doctrine includes depictions of the arising of suffering (anuloma-paṭiccasamuppāda, "with the grain", forward conditionality) and depictions of how the chain can be reversed (paṭiloma-paṭiccasamuppāda, "against the grain", reverse conditionality). These processes are expressed in various lists of dependently originated phenomena, the most well-known of which is the twelve links or nidānas (Pāli: dvādasanidānāni, Sanskrit: dvādaśanidānāni). The traditional interpretation of these lists is that they describe the process of a sentient being's rebirth in saṃsāra, and the resultant duḥkha (suffering, pain, unsatisfactoriness), and they provide an analysis of rebirth and suffering that avoids positing an atman (unchanging self or eternal soul). The reversal of the causal chain is explained as leading to the cessation of rebirth (and thus, the cessation of suffering).

In Buddhism, a mental fetter, chain or bond (Pāli: samyojana, Sanskrit: संयोजना, romanized: saṃyojana) shackles a sentient being to saṃsāra, the cycle of lives with dukkha. By cutting through all fetters, one attains nibbāna (Pali; Skt.: निर्वाण, nirvāṇa).

Bhaiṣajyaguru (Sanskrit: भैषज्यगुरु, Chinese: 藥師佛, Japanese: 薬師仏, Korean: 약사불, Vietnamese: Dược Sư Phật, Standard Tibetan: སངས་རྒྱས་སྨན་བླ), or Bhaishajyaguru, formally Bhaiṣajya-guru-vaiḍūrya-prabha-rāja ("Medicine Master and King of Lapis Lazuli Light"; Chinese: 藥師琉璃光(王)如來, Japanese: 薬師瑠璃光如来, Korean: 약사유리광여래, Vietnamese: Dược Sư Lưu Ly Quang Vương Như Lai), is the Buddha of healing and medicine in Mahāyāna Buddhism. Commonly referred to as the "Medicine Buddha", he is described as a doctor who cures suffering (Pali/Sanskrit: dukkha/duḥkha) using the medicine of his teachings.

The image of Bhaiṣajyaguru is usually expressed with a canonical Buddha-like form holding a gallipot and, in some versions, possessing blue or deep green skin. Though also considered to be a guardian of the East, in most cases, Akshobhya is given that role. As an exceptional case, the honzon of Mount Kōya's Kongōbu Temple was changed from Akshobhya to Bhaiṣajyaguru.

Rebirth in Buddhism refers to the teaching that the actions of a sentient being lead to a new existence after death, in an endless cycle called saṃsāra. This cycle is considered to be dukkha, unsatisfactory and painful. The cycle stops only if Nirvana (liberation) is achieved by insight and the extinguishing of craving. Rebirth is one of the foundational doctrines of Buddhism, along with karma and Nirvana. Rebirth was a key teaching of early Buddhism along with the doctrine of karma (which it shared with early Indian religions like Jainism). In Early Buddhist Sources, the Buddha claims to have knowledge of his many past lives. Rebirth and other concepts of the afterlife have been interpreted in different ways by different Buddhist traditions.

The rebirth doctrine, sometimes referred to as reincarnation or transmigration, asserts that rebirth takes place in one of the six realms of samsara, the realms of gods, demi-gods, humans, the animal realm, the ghost realm and hell realms. Rebirth, as stated by various Buddhist traditions, is determined by karma, with good realms favored by kusala karma (good or skillful karma), while a rebirth in evil realms is a consequence of akusala karma (bad or unskillful karma). While nirvana is the ultimate goal of Buddhist teaching, much of traditional Buddhist practice has been centered on gaining merit and merit transfer, whereby one gains rebirth in the good realms and avoids rebirth in the evil realms.