Duḥkha in the context of "Nirvana"

Buddhism, also known as Buddha-dharma and Dharmavinaya, is an Indian religion and philosophy based on teachings attributed to the Buddha, a śramaṇa and religious teacher who lived in the 6th or 5th century BCE. It is the world's fourth-largest religion, with about 320 million followers, known as Buddhists, who comprise 4.1% of the global population. It arose in the eastern Gangetic plain as a śramaṇa movement in the 5th century BCE, and gradually spread throughout much of Asia. Buddhism has subsequently played a major role in Asian culture and spirituality, eventually spreading to the West in the 20th century.

According to tradition, the Buddha instructed his followers in a path of cultivation that leads to awakening and full liberation from dukkha (lit. 'suffering'; 'unease', 'unsatisfactoriness') by attaining nirvana, the 'blowing out' (extinguishing) of the passions. He regarded this path as a Middle Way between extreme asceticism and sensory indulgence, and also between the extremes of eternalism and nihilism. Teaching that dukkha arises alongside attachment or clinging, the Buddha advised meditation practices and ethical precepts, rooted in non-harming. Widely observed teachings include the Four Noble Truths, the Noble Eightfold Path, and the doctrines of dependent origination, karma, and the three marks of existence. Other commonly observed elements include the Triple Gem, the taking of monastic vows, and the cultivation of perfections (pāramitā).

In Buddhism, the three marks of existence are three characteristics (Pali: tilakkhaṇa; Sanskrit: त्रिलक्षण trilakṣaṇa) of all existence and beings, namely anicca (impermanence), dukkha (commonly translated as "suffering" or "cause of suffering", "unsatisfactory", "unease"), and anattā (without a lasting essence). The concept of humans being subject to delusion about the three marks, this delusion resulting in suffering, and removal of that delusion resulting in the end of dukkha, is a central theme in the Buddhist Four Noble Truths, the last of which leads to the Noble Eightfold Path.

Bhaiṣajyaguru (Sanskrit: भैषज्यगुरु, Chinese: 藥師佛, Japanese: 薬師仏, Korean: 약사불, Vietnamese: Dược Sư Phật, Standard Tibetan: སངས་རྒྱས་སྨན་བླ), or Bhaishajyaguru, formally Bhaiṣajya-guru-vaiḍūrya-prabha-rāja ("Medicine Master and King of Lapis Lazuli Light"; Chinese: 藥師琉璃光(王)如來, Japanese: 薬師瑠璃光如来, Korean: 약사유리광여래, Vietnamese: Dược Sư Lưu Ly Quang Vương Như Lai), is the Buddha of healing and medicine in Mahāyāna Buddhism. Commonly referred to as the "Medicine Buddha", he is described as a doctor who cures suffering (Pali/Sanskrit: dukkha/duḥkha) using the medicine of his teachings.

The image of Bhaiṣajyaguru is usually expressed with a canonical Buddha-like form holding a gallipot and, in some versions, possessing blue or deep green skin. Though also considered to be a guardian of the East, in most cases, Akshobhya is given that role. As an exceptional case, the honzon of Mount Kōya's Kongōbu Temple was changed from Akshobhya to Bhaiṣajyaguru.

Saṃsāra (in Sanskrit (संसार) and Pali) in Buddhism is the beginningless cycle of repeated birth, mundane existence and dying again. Samsara is considered to be suffering (Skt. duḥkha; P. dukkha), or generally unsatisfactory and painful. It is perpetuated by desire and ignorance (Skt. avidyā; P. avijjā), and the resulting karma and sensuousness.

Rebirths occur in six realms of existence, namely three good realms (heavenly, demi-god, human) and three evil realms (animal, ghosts, hell). Saṃsāra ends when a being attains nirvāṇa, which is the extinction of desire and acquisition of true insight into the nature of reality as impermanent and non-self.

Advaita Vedanta (/ʌdˈvaɪtə vɛˈdɑːntə/; Sanskrit: अद्वैत वेदान्त, IAST: Advaita Vedānta) is a Hindu tradition of Brahmanical textual exegesis and philosophy, and a monastic institutional tradition nominally related to the Daśanāmi Sampradaya and propagated by the Smarta tradition. Its core tenet is that jivatman, the individual experiencing self, is ultimately pure awareness mistakenly identified with the body and its senses and with thought-constructs, and non-different from Ātman/Brahman, the highest Self or Reality. The term Advaita (अद्वैत) literally means "not-two" or "one without a second," which means that only Brahman, 'the one', is ultimately real while prapanca, 'the second', 'the world' or the multiplicity of thought-constructs, is not fully real. It is commonly rendered as "nonduality," and popularly interpreted as meaning that Atman is non-different from Brahman, and often equated with monism.

Advaita Vedanta is a Hindu sādhanā, a path of spiritual discipline and experience. It states that moksha (liberation from 'suffering' and rebirth) is attained through knowledge of Brahman, recognizing the illusoriness of the phenomenal world and disidentification from body-mind and the notion of 'doership', and by acquiring vidyā (knowledge) of one's true identity as Atman/Brahman, self-luminous (svayam prakāśa) awareness or Witness-consciousness. This knowledge is acquired through Upanishadic statements such as tat tvam asi, "that['s how] you are," which destroy the ignorance (avidyā) regarding one's true identity by revealing that (jiv)Ātman is non-different from immortal Brahman.