Drosophilidae in the context of "Drosophila melanogaster"

Drosophila (/drəˈsɒfɪlə, drɒ-, droʊ-/), from Ancient Greek δρόσος (drósos), meaning "dew", and φίλος (phílos), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly.

One species of Drosophila in particular, Drosophila melanogaster, has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "Drosophila" are often used synonymously with D. melanogaster in modern biological literature. The entire genus, however, contains more than 1,500 species and is very diverse in appearance, behavior, and breeding habitat.

On a July 9, 1946, suborbital V-2 rocket flight, fruit flies became the first living organisms to go to space, and on February 20, 1947, fruit flies safely returned from a suborbital space flight, which paved the way for human exploration. Years before sending mammals into space, such as the 1949 flight of the rhesus monkey Albert II, the Soviet space dogs, or humans, scientists studied Drosophila melanogaster (the common fruit fly) and its reactions to both radiation and space flight to understand the possible effects of space and a zero-gravity environment on humans. Starting in the 1910s, researchers conducted experiments on fruit flies because humans and fruit flies share many genes.

At the height of the Cold War and the Space Race, flies were sent on missions to space with great frequency, allowing scientists to study the nature of living and breeding in space. Scientists and researchers from the Soviet Union and the United States both used fruit flies for their research and missions. These flies were used to further the understanding of the effects of weightlessness on the cardiovascular system, the immune system, and the genes of astronauts.