Downtown St. Louis in the context of "Downtown West, St. Louis"

The Wainwright Building (also known as the Wainwright State Office Building) is a 10-story, 41 m (135 ft) terra cotta office building at 709 Chestnut Street in downtown St. Louis, Missouri. The Wainwright Building is considered to be one of the first aesthetically fully expressed early skyscrapers. It was designed by Dankmar Adler and Louis Sullivan and built between 1890 and 1891. It was named for local brewer, building contractor, and financier Ellis Wainwright.

The building, listed as a landmark both locally and nationally, is described as "a highly influential prototype of the modern office building" by the National Register of Historic Places. Architect Frank Lloyd Wright called the Wainwright Building "the very first human expression of a tall steel office-building as Architecture."

Washington University in St. Louis (WashU) is a private research university in St. Louis, Missouri, United States. Founded in 1853 by a group of civic leaders and named for George Washington, the university spans 355 acres across its Danforth and Medical campuses. It comprises nine schools and offers more than 150 undergraduate, 80 master's and professional, and 50 doctoral degree programs. As of 2024, Washington University enrolled 16,399 students representing all 50 U.S. states and more than 110 countries.

Established due to a concern of a lack of institutions of higher learning in the Midwest, the university held its first classes in 1854 in downtown St. Louis. In 1905, Washington University relocated to a new campus northwest of Forest Park, which allowed for expansion and new facilities to support its growing academic programs and student body. Construction of the first building, Busch Hall, began in 1900, followed by Brookings Hall, Ridgley, and Cupples. These buildings were not occupied until 1905 in order to accommodate the 1904 Summer Olympics and St. Louis World's Fair. By 1964, more than two-thirds of incoming students came from outside the St. Louis area. In 2021, the university adopted a need-blind undergraduate-admissions policy.

Ralcorp Holdings is an American manufacturer of various food products, including breakfast cereal, cookies, crackers, chocolate, snack foods, mayonnaise, pasta, and peanut butter. The company is based in St. Louis, Missouri. The majority of the items Ralcorp makes are private-label, store-brand products. It has over 9,000 employees. Ralcorp has its headquarters in the Bank of America Plaza in downtown St. Louis.

The Dome at America's Center is a multi-purpose stadium used for concerts, major conventions, and sporting events in downtown St. Louis, Missouri, United States. Previously known as the Trans World Dome from 1995 to 2001 and the Edward Jones Dome from 2002 to 2016, it was constructed largely to lure a National Football League (NFL) team to St. Louis and to serve as a convention space.

The Dome received its initial main tenant with the arrival of the NFL's St. Louis Rams, who relocated to the city in 1995. The Rams spent the next 21 seasons at the Dome, departing after the 2015 NFL season to return to Los Angeles. The St. Louis Battlehawks of the United Football League began playing at the stadium in early 2020, with Battlehawk fans commonly referring to the dome as the BattleDome.