Dolly (sheep) in the context of "1990s"

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⭐ Core Definition: Dolly (sheep)

Dolly (5 July 1996 – 14 February 2003) was a female Finn-Dorset sheep and the first mammal that was cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned.

The employment of adult somatic cells in lieu of embryonic stem cells for cloning emerged from the foundational work of John Gurdon, who cloned African clawed frogs in 1958 with this approach. The successful cloning of Dolly led to widespread advancements within stem cell research, including the discovery of induced pluripotent stem cells.

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👉 Dolly (sheep) in the context of 1990s

The 1990s (often referred and shortened to as "the '90s" or "the Nineties") was the decade that began on 1 January 1990, and ended on 31 December 1999. Known as the "post-Cold War decade", the 1990s were culturally imagined as the period from the Revolutions of 1989 until the September 11 attacks in 2001. The dissolution of the Soviet Union marked the end of Russia's status as a superpower, the end of a multipolar world, and the rise of anti-Western sentiment. China was still recovering from a politically and economically turbulent period. This allowed the US to emerge as the world's sole superpower, creating relative peace and prosperity for many western countries. During this decade, the world population grew from 5.3 to 6.1 billion.

The decade saw greater attention to multiculturalism and advance of alternative media. Public education about safe sex curbed HIV in developed countries. Generation X bonded over musical tastes. Humor in television and film was marked by ironic self-references mixed with popular culture references. Alternative music movements like grunge, reggaeton, Eurodance, K-pop, and hip-hop, became popular, aided by the rise in satellite and cable television, and the internet. New music genres such as drum and bass, post-rock, happy hardcore, denpa, and trance emerged. Video game popularity exploded due to the development of CD-ROM supported 3D computer graphics on platforms such as Sony PlayStation, Nintendo 64, and PCs.

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Dolly (sheep) in the context of Cloning

Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without a mate is known as parthenogenesis. In the field of biotechnology, cloning is the process of creating cloned organisms of cells and of DNA fragments.

The artificial cloning of organisms, sometimes known as reproductive cloning, is often accomplished via somatic-cell nuclear transfer (SCNT), a cloning method in which a viable embryo is created from a somatic cell and an egg cell. In 1996, Dolly the sheep achieved notoriety for being the first mammal cloned from a somatic cell. Another example of artificial cloning is molecular cloning, a technique in molecular biology in which a single living cell is used to clone a large population of cells that contain identical DNA molecules.

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Dolly (sheep) in the context of Somatic-cell nuclear transfer

In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking a denucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei.

"Therapeutic cloning" refers to the potential use of SCNT in regenerative medicine; this approach has been championed as an answer to the many issues concerning embryonic stem cells (ESCs) and the destruction of viable embryos for medical use, though questions remain on how homologous the two cell types truly are.

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LINKED FROM (PARENTS)
← 1990s ← Cloning ← Cloned ← Somatic-cell nuclear transfer
LINKS TO (CHILDREN)
Finn-Dorset → Mammal → Cloned → Somatic cell → Roslin Institute → Nuclear transfer → Mammary gland → Embryonic stem cell → John Gurdon → African clawed frog → Induced pluripotent stem cell →