Distomo (Greek: Δίστομο) is a town in western Boeotia, Greece. Since the 2011 local government reform, it is part of the municipality Distomo-Arachova-Antikyra, of which it is the seat and a municipal unit. The municipal unit has an area of 131.270 km, the community 80.498 km. As of 2021, the population is 3,644. Distomo is situated in the western foothills of Mount Helicon, at about 450 m elevation. It is 5 km north of the Gulf of Corinth coast, 9 km southeast of Arachova, 12 km east of Desfina, 16 km southeast of Delphi, 18 km west of Livadeia and 105 km northwest of Athens. The Greek National Road 48 (Naupactus - Arachova - Livadeia) passes north of the town.
Distomo is known as the site of the Distomo massacre that was perpetrated by the German army against the local inhabitants during the Second World War.
