Differential amplifier in the context of Electronic amplifier

In telecommunications and professional audio, a balanced line or balanced signal pair is an electrical circuit consisting of two conductors of the same type, both of which have equal impedances along their lengths, to ground, and to other circuits. The primary advantage of the balanced line format is good rejection of common-mode noise and interference when fed to a differential device such as a transformer or differential amplifier.

As prevalent in sound recording and reproduction, balanced lines are referred to as balanced audio.

In electronics, the common mode rejection ratio (CMRR) of a differential amplifier (or other device) is a metric used to quantify the ability of the device to reject common-mode signals, i.e. those that appear simultaneously and in-phase on both inputs. An ideal differential amplifier would have infinite CMRR, however this is not achievable in practice. A high CMRR is required when a differential signal must be amplified in the presence of a possibly large common-mode input, such as strong electromagnetic interference (EMI). An example is audio transmission over balanced line in sound reinforcement or recording.

The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level. A basic voltage clamp will iteratively measure the membrane potential, and then change the membrane potential (voltage) to a desired value by adding the necessary current. This "clamps" the cell membrane at a desired constant voltage, allowing the voltage clamp to record what currents are delivered. Because the currents applied to the cell must be equal to (and opposite in charge to) the current going across the cell membrane at the set voltage, the recorded currents indicate how the cell reacts to changes in membrane potential. Cell membranes of excitable cells contain many different kinds of ion channels, some of which are voltage-gated. The voltage clamp allows the membrane voltage to be manipulated independently of the ionic currents, allowing the current–voltage relationships of membrane channels to be studied.