Demetrius I Soter in the context of "Antiochus IV Epiphanes"

Andriscus (Ancient Greek: Ἀνδρίσκος, Andrískos; fl. 154/153 BC – 146 BC), also often referenced as Pseudo-Philip, was a Greek pretender who became the last independent king of Macedon in 149 BC as Philip VI (Ancient Greek: Φίλιππος, Philipos), based on his claim of being Philip, a now-obscure son of the last legitimate Macedonian king, Perseus. His reign lasted just one year and was toppled by the Roman Republic during the Fourth Macedonian War.

Ancient sources generally agree that he was originally a fuller from Adramyttium in Aeolis in western Anatolia. Around 153 BC, his ancestry was supposedly revealed to him, upon which he travelled to the court of his claimed uncle, the Seleucid monarch Demetrius I Soter, to request assistance in claiming his throne. Demetrius refused and had him sent to Rome, where he was judged harmless and exiled to a city in Italy; he managed to escape, and after gathering support, primarily from Thrace, he launched an invasion of Macedon, defeating Rome's clients and establishing his rule as king. The Romans naturally reacted militarily, triggering war; after some initial successes, Andriscus was defeated and captured by the praetor Quintus Caecilius Metellus Macedonicus, who subdued Macedon once again.

Tyche (/ˈtaɪki/; Ancient Greek: Τύχη Túkhē, 'Luck', Ancient Greek: [tý.kʰɛː], Modern Greek: [ˈti.çi]; Roman equivalent: Fortuna) was the presiding tutelary deity who governed the fortune and prosperity of a city, its destiny. In Classical Greek mythology, she is the daughter of the Titans Tethys and Oceanus, and she brings positive messages to people relating to external events outside their control.

During the Hellenistic period, with dramatic socio-political changes starting with Alexander the Great, Tyche increasingly embodied the whims of fate (both negative and positive), eclipsing the role of the Olympic gods. The Greek historian Polybius believed that when no cause can be discovered to events such as floods, droughts, frosts, or even in politics, then the cause of these events may be fairly attributed to Tyche. Other ancient Greek sources corroborate Polybius, such as Pindar who claims Tyche could hand victory to a lesser athlete. This "Hellenistic Tyche" is often featured on coins such as those minted by Demetrius I Soter. Further, Tyche comes to represent not only personal fate, but the fate of communities. Cities venerated their own Tychai, specific iconic versions of the original Tyche. This practice was continued in the iconography of Roman art, even into the Christian period, often as sets of the greatest cities of the empire.

Timarchus (Greek: Τίμαρχος, Tímarchos) also known as Timarch, was a Greek noble and a satrap of the Seleucid Empire during the reign of his ally King Antiochus IV Epiphanes. After Antiochus IV's death, he styled himself an independent ruler in his domain in the Persian east of the Empire from around 163–160 BC, and may have even sought to entirely usurp leadership of the entire empire. He gained an alliance with the Roman Republic, which sought to weaken the Seleucid Empire by promoting internal divisions; both Rome and Timarchus distrusted the new king Demetrius I. Demetrius rode east and defeated Timarchus in 160 BC, ending his short reign.

Alexander I Theopator Euergetes, surnamed Balas (Ancient Greek: Ἀλέξανδρος Βάλας, romanized: Alexandros Balas), was the ruler of the Seleucid Empire from 150 BC to August 145 BC. Picked from obscurity and supported by the neighboring Roman-allied Kingdom of Pergamon, Alexander landed in Phoenicia in 152 BC and started a civil war against Seleucid King Demetrius I Soter. Backed by mercenaries and factions of the Seleucid Empire unhappy with the existing government, he defeated Demetrius and took the crown in 150 BC. He married the princess Cleopatra Thea to seal an alliance with the neighboring Ptolemaic kingdom. His reign saw the steady retreat of the Seleucid Empire's eastern border, with important eastern satrapies such as Media being lost to the nascent Parthian Empire. In 147 BC, Demetrius II Nicator, the young son of Demetrius I, began a campaign to overthrow Balas, and civil war resumed. Alexander's ally, Ptolemaic king Ptolemy VI Philometor, moved troops into Coele-Syria to support Alexander, but then switched sides and threw his support behind Demetrius II. At the Battle of the Oenoparus River in Syria, he was defeated by Ptolemy VI and he died shortly afterward.

Demetrius II Nicator (Ancient Greek: Δημήτριος Β`, Dēmḗtrios B; Ancient Greek: Νικάτωρ, Nikátōr, "Victor"; died 125 BC) was one of the sons of Demetrius I Soter. His mother may have been Laodice V, as was the case with his brother Antiochus VII Sidetes. Demetrius ruled the Seleucid Empire for two periods, separated by a number of years of captivity in Hyrcania in Parthia, first from September 145 BC to July/August 138 BC, and again from 129 BC until his death in 125 BC. His brother Antiochus VII ruled the Seleucid Empire in the interim between his two reigns.