Deir ez-Zor in the context of "Busayrah"

The 1966 Syrian coup d'état (also known as the 23 February Movement) refers to events between 21 and 23 February during which the government of the Syrian Arab Republic was overthrown and replaced. The ruling National Command of the Arab Socialist Ba'ath Party were removed from power by a union of the party's Military Committee and the Syrian Regional Branch, under the leadership of Salah Jadid.

The coup was precipitated by a heightening in the power struggle between the party's old guard, represented by Michel Aflaq, Salah al-Din al-Bitar, and Munif al-Razzaz, and the radical leftist factions adhering to a Neo-Ba'athist position. On 21 February, supporters of the old guard in the army ordered the transfer of their rivals. Two days later, the Military Committee, backing the radical leftist factions, launched a coup that involved violent fighting in Aleppo, Damascus, Deir ez-Zor, and Latakia. As a result of the coup, the party's historical founders fled the country and spent the rest of their lives in exile.

On 27 November 2024, a coalition of Syrian revolutionary factions called the Military Operations Command, led by Hay'at Tahrir al-Sham (HTS) and supported by allied Turkish-backed groups in the Syrian National Army (SNA), launched an offensive against the Ba'athist regime's armed forces in Idlib, Aleppo and Hama Governorates in Syria. It initially began as a localised offensive targeting towns in the Idlib and Aleppo countryside, later evolving into a nationwide campaign that culminated in the toppling of Bashar al-Assad’s regime.

On 29 November 2024, HTS and later the Syrian Democratic Forces (SDF) entered Aleppo and captured most of the city, amid the collapse of pro-government forces. The next day, opposition forces made rapid advances, capturing dozens of towns and villages as pro-government forces disintegrated, and advanced toward Hama in central Syria, subsequently capturing it on 5 December. By 6 December, the SDF captured Deir ez-Zor in an offensive east of the Euphrates, while the newly formed Southern Operations Room and Al-Jabal Brigade captured Daraa and Suwayda in an offensive in the south. The HTS advanced further south toward Homs. The US-backed Syrian Free Army (SFA) took control of Palmyra in the southeast of the country.

Mari (Cuneiform: 𒈠𒌷𒆠, ma-ri, modern Tell Hariri; Arabic: تل حريري) was an ancient Semitic city-state in modern-day Syria. Its remains form a tell 11 kilometres (6.8 mi) north-west of Abu Kamal on the western bank of the Euphrates River, some 120 kilometres (75 mi) southeast of Deir ez-Zor. It flourished as a trade center and hegemonic state between 2900 BC and 1759 BC. The city was built in the middle of the Euphrates trade routes between Sumer in the south and the Eblaite kingdom and the Levant in the west.

Mari was first abandoned in the middle of the 26th century BC but was rebuilt and became the capital of a hegemonic East Semitic state before 2500 BC. This second Mari engaged in a long war with its rival Ebla and is known for its strong affinity with Sumerian culture. It was destroyed in the 23rd century BC by the Akkadians, who allowed the city to be rebuilt and appointed a military governor (Shakkanakku). The governors became independent with the disintegration of the Akkadian Empire, and rebuilt the city as a regional center of the Euphrates valley. The Shakkanakkus ruled Mari until the second half of the 19th century BC, when the dynasty collapsed for unknown reasons. A short time later, Mari became the capital of the Amorite Lim dynasty. The Amorite Mari lasted only a short time before it was destroyed by Babylonia in c. 1761 BC, but it survived as a small settlement under the rule of the Babylonians and the Assyrians before being abandoned and forgotten during the Hellenistic period.

Al-Salihiyah (Arabic: الصالحية; also spelled Salhiyé) is a town in eastern Syria, administratively part of the Deir ez-Zor Governorate, located on the western bank of the Euphrates River, south of Deir ez-Zor. Nearby localities include al-Asharah, Mayadin and al-Muhasan to the north and Hajin and al-Jalaa to the south. According to the Syria Central Bureau of Statistics, al-Salihiyah had a population of 4,471 in the 2004 census. The village is located just next to the site of ancient Dura-Europos.

Deir ez-Zor Governorate (Arabic: مُحافظة دير الزور Muḥāfaẓat Dayr az-Zawr; Kurdish: Parêzgeha Dêrezor) is one of the fourteen governorates (provinces) of Syria. It is situated in eastern Syria, bordering Iraq. It has an area of 33,060 km (12,760 sq mi) and a population of 1,239,000 (2011 estimate). The capital is Deir ez-Zor. It is divided roughly equally from northwest to southeast by the Euphrates. Most of the territory on the river's left (northeast) bank is part of the Democratic Autonomous Administration of North and East Syria (DAANES), while that on the right (southwest) bank is controlled by the Syrian transitional government (STG).

The Battle of Hawija was an offensive launched in September 2017 by the Iraqi Army, in order to recapture the town of Hawija and the surrounding areas from the Islamic State (IS).

The offensive was concurrent with the 2017 Central Syria campaign by the Syrian Army to capture IS territory towards Deir ez-Zor, as well as with the Raqqa campaign (2016–17) conducted by the Syrian Democratic Forces (SDF) against IS's de facto capital city and stronghold in Syria.

The Eastern Syria campaign of September–December 2017 was a large-scale military operation of the Syrian Army (SAA) and its allies against the Islamic State of Iraq and the Levant (ISIL) during the Syrian Civil War. Its goal was to clear the city of Deir ez-Zor of any remaining ISIL forces, capture ISIL's de facto capital of Mayadin, as well as seize the border town of Abu Kamal, which became one of ISIL's final urban strongholds by the latter stages of the campaign.

The campaign was concurrent with the 2017 Western Iraq campaign, the Raqqa campaign conducted by the Syrian Democratic Forces (SDF) against ISIL's former capital city of Raqqa, as well as with the SDF's offensive in Deir ez-Zor province along the eastern banks of the Euphrates River.