Cius in the context of "Mithridates I of Pontus"

The Mithridatic dynasty, also known as the Pontic dynasty, was a hereditary dynasty of Persian origin, founded by Mithridates I Ktistes (Mithridates III of Cius) in 281 BC. The origins of the dynasty were located in the highest circles of the ruling Persian nobility in Cius. Mithridates III of Cius fled to Paphlagonia after the murder of his father and his predecessor Mithridates II of Cius, eventually proclaiming the Kingdom of Pontus, and adopting the epithet of "Ktistes" (literally, Builder). The dynasty reached its greatest extent under the rule of Mithridates VI, who is considered the greatest ruler of the Kingdom of Pontus.

They were prominent enemies of the Roman Republic during the Mithridatic Wars during the reign of Mithridates VI until the late 60s BC. In 48 BC, the Roman client king of the Crimea, Pharnaces II, attempted to press his claim on Pontus, but was decisively defeated by Julius Caesar at the Battle of Zela.

Nea Kios (Greek: Νέα Κίος) is a small town and former municipality in Argolis, Peloponnese, Greece. Since the 2011 local government reform it is part of the municipality Argos-Mykines, of which it is a municipal unit. The emblem of the town is Argo. The municipal unit has an area of 5.700 km. It was founded by refugees from Cius in Bithynia after the expulsion of the Greeks from Asia Minor.

Ariobarzanes (Old Persian: *Aryābr̥zaⁿs; Ancient Greek: Ἀριοβαρζάνης Ariobarzánēs; death: crucified in c. 362 BCE), sometimes known as Ariobarzanes I of Cius, was a Persian Satrap of Phrygia and military commander, leader of an independence revolt, and the first known of the line of rulers of the Greek town of Cius who eventually were to stem the kings of Pontus in the 3rd century BCE.Ariobarzanes was apparently a cadet member of the Achaemenid dynasty, possibly son of Pharnabazus II, and part of the Pharnacid dynasty which had settled to hold Dascylium of Hellespont in the 470s BCE. Cius is located near Dascylium, and Cius seemingly was a share of family holdings for the branch of Ariobarzanes.

Ariobarzanes' one predecessor was a (kinsman) named Mithradates (possibly Mithradates, Satrap of Cappadocia). The archaeologist Walther Judeich claims that Ariobarzanes was that Mithradates' son, but Brian C. McGing refutes that specific filiation. Seemingly, no classical source itself calls them son and father, the filiation being a later reconstruction on basis of successorship.

Gemlik is a municipality and district of Bursa Province, Turkey. Its area is 401 km, and its population is 120,245 (2022). It is located in the east of the Gulf of Gemlik. It is approximately 29 km (18 mi) away from Bursa. In antiquity, Gemlik was the location of the ancient Greek town of Cius.

Gemlik is an industrial port and has a freezone trade center. There are also important industrial establishments in the south and west of the harbors. The port of Gemlik is one of the busiest import harbors in Turkey. Gemlik is renowned for black olives.

Mithridates of Cius (in Greek Mιθριδάτης or Mιθραδάτης; lived c. 386–302 BCE, ruled 337–302 BCE) a Persian noble, succeeded his kinsman or father Ariobarzanes II in 337 BCE as ruler of the Greek town of Cius in Mysia (today part of Turkey). Diodorus assigns him a rule of thirty-five years, but it appears that his rule of Cius was interrupted during that period. What circumstances led to his expulsion or subjection are unknown; nothing is heard of him until his death in 302 BCE. However, it appears that he had submitted to the Macedonian Antigonus, who, to prevent him from joining the league of Cassander and his confederates, arranged for his assassination in Cius.

According to Lucian, he was at least eighty-four years of age at the time of his death, which makes it likely that he is the same person as the Mithridates, son of Ariobarzanes, who in his youth circumvented and put to death Datames. King Mithridates I of Pontus was his kinsman, although it is not known whether he was his son.

Asclepiades (Greek: Ἀσκληπιάδης; c. 129/124 BC – 40 BC), sometimes called Asclepiades of Bithynia or Asclepiades of Prusa, was a Greek physician born at Prusias-on-Sea in Bithynia in Anatolia and who flourished at Rome, where he practised and taught Greek medicine. He attempted to build a new theory of disease, based on the flow of "atoms" through pores in the body. His treatments sought to restore harmony through the use of diet, exercise, and bathing.

Biographer Antonio Cocchi noted that there were over forty men of history with the name Asclepiades and wrote that physician Caius Calpurnius Asclepiades of Prusa, born 88 CE, was a fellow countryman of, and perhaps a direct descendant of this Asclepiades.