Chyme or chymus (/ˈkaɪməs/; from Ancient Greek χυμός (khumós) 'juice') is the semi-fluid mass of partly digested food and digestive secretions that is formed in and expelled by the stomach, through the pyloric valve, into the duodenum (the beginning of the small intestine), where it is further transformed. Chyme also contains cells from the mouth and esophagus that slough off from the mechanical action of chewing and swallowing.
Chyme results from the mechanical and chemical breakdown of a bolus and consists of partially digested food, water, hydrochloric acid, and various digestive enzymes. Chyme slowly passes through the pyloric sphincter and into the duodenum, where the extraction of nutrients begins. Depending on the quantity and contents of the meal, the stomach will digest the food into chyme in some time from 40 minutes to 3 hours. With a pH of approximately 2, chyme emerging from the stomach is very acidic. The duodenum, a short section of the small intestine located between the stomach and the rest of the small intestine, secretes a hormone, cholecystokinin (CCK), which causes the gallbladder to contract, releasing alkaline bile into the duodenum and reducing the chyme's low pH. CCK also causes the release of digestive enzymes from the pancreas. The duodenum also produces the hormone secretin to stimulate the pancreatic secretion of large amounts of sodium bicarbonate, which then raises pH of the chyme to 7. Other secretions from the liver and from glands in the intestinal wall help in digestion, as these secretions contain a variety of digestive enzymes and chemicals that assist in the breakdown of complex compounds into those that can be absorbed and used by the body.
