Charles V, Holy Roman Emperor in the context of "County of Flanders"

Peru, officially the Republic of Peru, is a country in western South America. It is bordered to the north by Ecuador and Colombia, to the east by Brazil, to the southeast by Bolivia, to the south by Chile, and to the south and west by the Pacific Ocean. Peru is a megadiverse country, with habitats ranging from the arid plains of the Pacific coastal region in the west, to the peaks of the Andes mountains extending from the north to the southeast of the country, to the tropical Amazon basin rainforest in the east with the Amazon River. Peru has a population of over 32 million, and its capital and largest city is Lima. At 1,285,216 km (496,225 sq mi), Peru is the 19th largest country in the world, and the third largest in South America.

Peruvian territory was home to several cultures during the ancient and medieval periods, and has one of the longest histories of civilization of any country, tracing its heritage back to the 10th millennium BCE Caral–Supe civilization, the earliest civilization in the Americas and considered one of the cradles of civilization. Notable succeeding cultures and civilizations include the Nazca culture, the Moche, Wari and Tiwanaku empires, the Kingdom of Cusco, and the Inca Empire, the largest known state in the pre-Columbian Americas. The Spanish Empire conquered the region in the 16th century and Charles V established a viceroyalty with the official name of the Kingdom of Peru that encompassed most of its South American territories, with its capital in Lima. Higher education started in the Americas with the official establishment of the National University of San Marcos in Lima in 1551.

The National University of San Marcos (Spanish: Universidad Nacional Mayor de San Marcos, UNMSM) is a public research university located in Lima, the capital of Peru. In the Americas, it is the first officially established (privilege by Charles V, Holy Roman Emperor) and the oldest continuously operating university.

The university started in the general studies that were offered in the convent of the Rosario of the order of Santo Domingo—the current Basilica and Convent of Santo Domingo—in around 1548. Its official foundation was conceived by Fray Thomas de San Martín on May 12, 1551; with the decree of Emperor Charles I of Spain and V of the Holy Roman Empire. In 1571, it acquired the degree of pontifical granted by Pope Pius V, with which it ended up being named the "Royal and Pontifical University of the City of the Kings of Lima". It is also referred to as the "University of Lima" throughout the Viceroyalty.

In art history, the High Renaissance was a short period of the most exceptional artistic production in the Italian states, particularly Rome, capital of the Papal States, and in Florence, during the Italian Renaissance. Most art historians state that the High Renaissance started between 1490 and 1500, and ended in 1520 with the death of Raphael, although some say the High Renaissance ended about 1525, or in 1527 with the Sack of Rome by the mutinous army of Charles V, Holy Roman Emperor, or about 1530. The best-known exponents of painting, sculpture, and architecture of the High Renaissance include Leonardo da Vinci, Michelangelo, Raphael, and Bramante. In the 21st century, the use of the term has been frequently criticized by some academic art historians for oversimplifying artistic developments, ignoring historical context, and focusing only on a few iconic works.

The phrase "the empire on which the sun never sets" has been used to describe the British Empire due to it being so territorially extensive that it seemed as though it was always daytime in at least one part of their territories. Previously, the concept referred to the Spanish Empire under Philip II and his successors, particularly in the 16th, 17th, and 18th centuries. The phrase originated to describe the empire of Charles V and derived from similar ancient claims of universal rule referring to the Roman and Persian empires.

The Habsburg monarchy, also known as Habsburg Empire, or Habsburg Realm (/ˈhæpsbɜːrɡ/), and Danube Monarchy, was the collection of empires, kingdoms, duchies, counties and other polities (composite monarchy) that were ruled by the House of Habsburg. From 1804 it was referred to as the Austrian Empire, and from 1867 as Austria-Hungary.

The history of the Habsburg monarchy can be traced back to the election of Rudolf I as King of Germany in 1273 and his acquisition of the Duchy of Austria for the Habsburgs in 1282. In 1482, Maximilian I acquired the Netherlands through marriage. Both realms passed to his grandson and successor, Charles V, who also inherited the Spanish throne and its colonial possessions, and thus came to rule the Habsburg empire at its greatest territorial extent. The abdication of Charles V in 1556 led to a division within the dynasty between his son Philip II of Spain and his brother Ferdinand I, who had served as his lieutenant and the elected king of Hungary, Croatia and Bohemia. The Spanish branch (which held all of Iberia, the Netherlands, and lands in Italy) became extinct in the male line in 1700, but continued through the female line through the House of Bourbon. The Austrian branch (which ruled the Holy Roman Empire, Hungary, Bohemia and various other lands) was itself split into different branches in 1564 but reunited 101 years later. It became extinct in the male line in 1740, but continued through the female line as the House of Habsburg-Lorraine.

Habsburg Spain refers to Spain and the Hispanic Monarchy, also known as the Catholic Monarchy, in the period from 1516 to 1700 when it was ruled by kings from the House of Habsburg. In this period the Spanish Empire was at the zenith of its influence and power. During this period, Spain held many territories, including Pan-American continental holdings and the West Indies; European territories like the Low Countries, Italian territories, Portugal and parts of France; and the Philippines and other possessions in Southeast Asia. The period of Spanish history has also been referred to as the "Age of Expansion".

The Habsburg name was not always used by the family members, who often emphasized their more prestigious princely titles. The dynasty was long known as the "House of Austria". In some circumstances, the family members were identified by their birthplace. Thus, Charles V was known in his youth as Charles of Ghent. As king of Spain, he was known as Charles I of Spain and as emperor, Charles V (in French, Charles Quint). In Spain, the dynasty was known as the Casa de Austria, including illegitimate sons such as John of Austria and John Joseph of Austria. The arms displayed in their simplest form were those of Austria, which the Habsburgs had made their own, at times impaled with the arms of the Duchy of Burgundy (ancient), as seen on the arms of John of Austria. Calling this era "Habsburg", is, to some extent, a convenience for historians.

Juan Sebastián Elcano (Elkano in modern Basque; also known as del Cano; 1486/1487 – 4 August 1526) was a Spanish navigator, ship-owner and explorer of Basque origin, best known for having completed the first circumnavigation of the Earth in the Spanish ship Victoria on the Magellan expedition to the Spice Islands. He received recognition for his achievement by Charles I of Spain with a coat of arms bearing a globe and the Latin motto Primus circumdedisti me (You were the first to circumnavigate me).

Despite his achievements, information on Elcano is scarce and he is the subject of great historiographical controversy, because of the scarcity of original sources which illuminate his private life and personality. Even in Spain, for example, the first biographies about him were written in the second half of the 19th century, after three centuries of neglect by historians.