Ferrante II Gonzaga (1563 – 6 August 1630) was count and, from 1621, duke of Guastalla.
He was the son of Cesare I Gonzaga, count of Guastalla and duke of Amalfi, and Donna Camilla Borromeo. He succeeded his father in 1575. On 2 July 1621, the County of Guastalla was elevated to a duchy and Ferrante was subsequently deemed a duke.