Carlisle, Pennsylvania in the context of "South Central Pennsylvania"

The United States Army War College (USAWC) is a U.S. Army staff college in Carlisle Barracks, Pennsylvania, with a Carlisle postal address, on the 500-acre (2 km) campus of the historic Carlisle Barracks. It provides graduate-level instruction to senior military officers, government officials, and civilians to prepare them for senior leadership assignments and responsibilities. Each year, a number of Army colonels and lieutenant colonels are considered by a board for admission. Approximately 800 students attend at any one time, half in a two-year-long distance learning program, and the other half in an on-campus, full-time resident program lasting ten months. Upon completion, the college grants its graduates a master's degree in Strategic Studies (MSS).

The Army War College is a split-functional institution. Emphasis is placed on research and students are also instructed in leadership, strategy, and joint-service/international operations. It is one of the senior service colleges including the Naval War College and the USAF Air War College. Additionally, the U.S. Department of Defense operates the National War College.

Carlisle Barracks is a United States Army facility located in Pennsylvania, with a Carlisle post office address and with a portion in Carlisle, Pennsylvania. The site of the U.S. Army War College, it is the nation's second-oldest active military base. The first structures were built in 1757, during the French and Indian War between Great Britain and France in the colonies.

From 1879 to 1918, the property was transferred to the Department of Interior to operate the Carlisle Indian Industrial School. This was the first off-reservation boarding school established to educate and assimilate Native American children into European-American culture. In 1891 Congress passed legislation to expand this program. After the United States entered World War I, the school was closed and the property was transferred back to the War Department.

The United States Indian Industrial School in Carlisle, Pennsylvania, generally known as Carlisle Indian Industrial School, was the flagship Indian boarding school in the United States from its founding in 1879 to 1918. It was based in the historic Carlisle Barracks, which was transferred to the Department of Interior from the War Department for the purpose of establishing the school. Throughout its history, over 7,800 children from 140 Native American tribes were enrolled at the school. After the United States entered World War I, the school was closed, and the property was transferred back for use by the U.S. Department of Defense. The property is now part of the U.S. Army War College.

In December 2024, it was designated a national monument by President Joe Biden called the Carlisle Federal Indian Boarding School National Monument and co-managed by the Army and the National Park Service in consultation with Native American tribes.

The Giant Company (formerly known as Giant Food Stores) is an American regional supermarket chain that operates in Pennsylvania, Maryland, Virginia, and West Virginia under the Giant and Martin's brands. It is a subsidiary of Ahold Delhaize, and headquartered in Carlisle, Pennsylvania. As of May 2025, the company operated 193 stores, 133 pharmacies, and 107 fuel stations. The chain also provides online shopping and delivery to New Jersey through Giant Direct.

The Giant Company is often known as Giant-Carlisle or Giant/Martin's to distinguish it from Giant Food, a Maryland-headquartered sister chain also owned by Ahold Delhaize and often referred to as Giant-Landover.