Harrisburg–Carlisle metropolitan statistical area in the context of "Carlisle, Pennsylvania"

Harrisburg (/ˈhærɪsbɜːrɡ/ HARR-iss-burg; Pennsylvania German: Harrisbarrig) is the capital city of the U.S. commonwealth of Pennsylvania. It is the ninth-most populous city in the state, with a population of 50,099 at the 2020 census, while the Harrisburg–Carlisle metropolitan statistical area has an estimated 615,000 residents and is the fourth-most populous metropolitan area in Pennsylvania. Harrisburg is situated on the east bank of the Susquehanna River 83 miles (134 km) southwest of Allentown and 107 miles (172 km) northwest of Philadelphia. It is officially incorporated as a third-class city and is the county seat of Dauphin County.

Harrisburg played a role in American history during the Westward Migration, the American Civil War, and the Industrial Revolution. During part of the 19th century, the building of the Pennsylvania Canal and later the Pennsylvania Railroad allowed Harrisburg to develop into one of the most industrialized cities in the Northeastern United States. In the mid- to late 20th century, the city's economic fortunes fluctuated with its major industries consisting of government, heavy manufacturing, agriculture, and food services. These economic fluctuations contributed to Harrisburg experiencing a decline of nearly half its population between 1950 and 2000. However, the region is seen as financially stable in part due to the high concentration of state and federal government agencies.

The Wyoming Valley is a historic industrialized region of Northeastern Pennsylvania. The region is historically notable for its influence in helping fuel the American Industrial Revolution with its many anthracite coal mines. As a metropolitan area, it is known as the Scranton–Wilkes-Barre metropolitan area, after its principal cities, Scranton and Wilkes-Barre. With a population of 567,559 as of the 2020 United States census, it is the fifth-largest metropolitan area in Pennsylvania, after the Delaware Valley, Greater Pittsburgh, the Lehigh Valley, and the Harrisburg–Carlisle metropolitan statistical areas.

Within the geology of Pennsylvania the Wyoming Valley makes up its own unique physiographic province, the Anthracite Valley. Greater Pittston occupies the center of the valley. Scranton is the most populated city in the metropolitan area with a population of 77,114. The city of Scranton grew in population after the 2015 mid-term census while Wilkes-Barre declined in population. Wilkes-Barre remains the second most-populated city in the metropolitan area, while Hazleton is the third most-populated city in the metropolitan area.

Enola is a census-designated place (CDP) located along the Susquehanna River in East Pennsboro Township, Cumberland County, Pennsylvania, United States. The population was 6,111 at the 2010 census. Norfolk Southern operates Enola Yard, a large rail yard and locomotive shop in Enola. It is situated in Cumberland County, directly across the Susquehanna River from Harrisburg and is part of the Harrisburg–Carlisle metropolitan statistical area.