Giovanni Ponzello (or Ponsello) (Caravonica, 1520 – Genoa, 1598) was an Italian mannerist architect active in the Republic of Genoa, where he supervised the construction of several distinguished palaces and churches during the Renaissance period.
Several of his works are included in the UNESCO World Heritage Site Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli.