Capsule (pharmacy) in the context of "Dosage form"

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⭐ Core Definition: Capsule (pharmacy)

In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The two main types of capsules are:

  • Hard-shelled capsules, which contain dry, powdered ingredients or miniature pellets made by e.g. processes of extrusion or spheronization. These are made in two-halves: a smaller-diameter "body" that is filled and then sealed using a larger-diameter "cap".
  • Soft-shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil.

Both of these classes of capsules are made from aqueous solutions of gelling agents, such as animal protein (mainly gelatin) or plant polysaccharides or their derivatives (such as carrageenans and modified forms of starch and cellulose). Other ingredients can be added to the gelling agent solution including plasticizers such as glycerin or sorbitol to decrease the capsule's hardness, coloring agents, preservatives, disintegrants, lubricants and surface treatment.

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👉 Capsule (pharmacy) in the context of Dosage form

Dosage forms (also called unit doses) are pharmaceutical drug products presented in a specific form for use. They contain a mixture of active ingredients and inactive components (excipients), configured in a particular way (such as a capsule shell) and apportioned into a specific dose. For example, two products may both be amoxicillin, but one may come in 500 mg capsules, while another may be in 250 mg chewable tablets.

The term unit dose can also refer to non-reusable packaging, particularly when each drug product is individually packaged. However, the FDA differentiates this by referring to it as unit-dose "packaging" or "dispensing". Depending on the context, multi(ple) unit dose may refer to multiple distinct drug products packaged together or a single product containing multiple drugs and/or doses.

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Capsule (pharmacy) in the context of Gelatin

Gelatin or gelatine (from Latin gelatus 'stiff, frozen') is a translucent, colorless, flavorless food ingredient, commonly derived from collagen taken from animal body parts. It is brittle when dry and rubbery when moist. It may also be referred to as hydrolyzed collagen, collagen hydrolysate, gelatine hydrolysate, hydrolyzed gelatine, and collagen peptides after it has undergone hydrolysis. It is commonly used as a gelling agent in food, beverages, medications, drug or vitamin capsules, photographic films, papers and cosmetics.

Substances containing gelatin or functioning in a similar way are called gelatinous substances. Gelatin is an irreversibly hydrolyzed form of collagen, wherein the hydrolysis reduces protein fibrils into smaller peptides; depending on the physical and chemical methods of denaturation, the molecular weight of the peptides falls within a broad range. Gelatin is present in gelatin desserts, most gummy candy and marshmallows, ice creams, dips, and yogurts. Gelatin for cooking comes as powder, granules, and sheets. Instant types can be added to the food as they are; others must soak in water beforehand.

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Capsule (pharmacy) in the context of Probiotic

Probiotics are live microorganisms in that are intended to support or improve the health and wellbeing of a host organism. They are commonly used in both humans and animals. Although the term refers to the microorganisms themselves, probiotics can be consumed through a range of products including yogurt, cheese, certain fermented foods (such as nattō), as well as capsules containing a single strain or a defined mixture of strains.

Probiotics are regarded as generally recognised as safe (GRAS) by the U.S. Food and Drug Administration (FDA), which supports their safety when used as intended, although this designation does not establish their effectiveness or specific health benefits. Many claimed health benefits, such as treating eczema or curing vaginal infections, lack substantial scientific support.

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Capsule (pharmacy) in the context of Absorption (pharmacology)

Absorption is the journey of a drug travelling from the site of administration to the site of action.

The drug travels by some route of administration (oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution). Absorption by some other routes, such as intravenous therapy, intramuscular injection, enteral nutrition, is even more straightforward and there is less variability in absorption and bioavailability is often near 100%. Intravascular administration does not involve absorption, and there is no loss of drug. The fastest route of absorption is inhalation.

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Capsule (pharmacy) in the context of Dietary supplement

A dietary supplement is a manufactured product intended to supplement a person's diet in the form of a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients that are either extracted from food sources or are synthesized (to increase the quantity of their consumption). The classes of nutrient compounds in supplements include vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements may also contain substances that have not been confirmed as being essential to life, such as plant pigments or polyphenols, and so, by definition, are not necessarily nutrients. However, they may still be marketed as having a beneficial biological effect. Animals can also be a source of supplement ingredients; for example, collagen may be extracted from chickens or fish. Supplements are sold in multiple doses, ranging from one time usage to entire courses. They may also be enhanced with nutrient ingredients.

In the United States, the supplement industry was estimated to have a value of $151.9 billion in 2021. There are more than 50,000 dietary supplement products marketed in the United States, and about 50% of the American adult population consumes dietary supplements. Multivitamins are the most commonly used product among types of dietary supplements. The United States National Institutes of Health (NIH) states that some supplements may help provide essential nutrients or support overall health and performance for those with limited dietary variety.

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Capsule (pharmacy) in the context of Chicago Tylenol murders

The Chicago Tylenol murders were a series of poisoning deaths resulting from drug tampering in the Chicago metropolitan area in 1982. The victims consumed Tylenol branded acetaminophen (paracetamol) powder-filled capsules that had been adulterated with potassium cyanide. At least seven people died in the original poisonings, and there were several more deaths in subsequent copycat crimes.

No suspect has been charged or convicted of the poisonings as of 2025. New York City resident James William Lewis was convicted of extortion for sending a letter to Tylenol's then-manufacturer, Johnson & Johnson, that claimed responsibility for the deaths and demanded $1 million to stop them, but when he was discovered, he said the letter's claim was false, and further investigation failed to establish his involvement. The incidents led to a discontinuation of the use of powder-filled capsules for over-the-counter medicines, reforms in medication packaging, and federal anti-tampering laws.

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