Cancer research in the context of "Paul Uhlenhuth"

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⭐ Core Definition: Cancer research

Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure.

Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy.

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👉 Cancer research in the context of Paul Uhlenhuth

Paul Theodor Uhlenhuth (7 January 1870 in Hanover – 13 December 1957 in Freiburg im Breisgau) was a German bacteriologist and immunologist, and Professor at the University of Strasbourg (1911–1918), at the University of Marburg (1918–1923) and at the University of Freiburg (1923–1936). He was a rector of the University of Freiburg from 1928 to 1929. After his retirement in 1936, he led his own research institute in Freiburg, known as the State Research Laboratory, until his death in 1957.

He is famous in the annals of forensic science for developing the species precipitin test, known as the Uhlenhuth test, which could distinguish human blood from animal blood in 1901, a discovery which had tremendous importance in criminal justice in the 20th century. In 1915, he discovered the pathogen of Weil's disease. He also invented the arsenic treatment of syphilis and the antimony treatment of many tropical diseases, and was an influential promoter of cancer research. He was a recipient of numerous honours, and was a member of the Academy of Sciences Leopoldina and the Royal Swedish Academy of Sciences. He was nominated for the Nobel Prize in Medicine 40 times between 1910 and 1952, notably by Nobel laureate Karl Landsteiner. At the time of his death, he was one of the most celebrated medical researchers in Germany, and one of the rare examples of someone who was equally celebrated in the west and east during the Cold War.

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Cancer research in the context of Electron lens

Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a detector such as a scintillator attached to a charge-coupled device or a direct electron detector.

Transmission electron microscopes are capable of imaging at a significantly higher resolution than light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands of times smaller than a resolvable object seen in a light microscope. Transmission electron microscopy is a major analytical method in the physical, chemical and biological sciences. TEMs find application in cancer research, virology, and materials science as well as pollution, nanotechnology and semiconductor research, but also in other fields such as paleontology and palynology.

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Cancer research in the context of Genetically modified mouse

A genetically modified mouse, genetically engineered mouse model (GEMM) or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common in vivo models in cancer research. The two approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics.

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