Invasion is the process by which cancer cells directly extend and penetrate into neighboring tissues in cancer. It is generally distinguished from metastasis, which is the spread of cancer cells through the circulatory system or the lymphatic system to more distant locations. The two are nonetheless closely related, and lymphovascular invasion is generally the first step of metastasis.
The two main patterns of cancer cell invasion by cell migration are collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. Either pattern of cell migration exhibits distinct morphological features and is governed by specific biochemical and molecular genetic mechanisms.