Bone tumor in the context of "Leukocytosis"

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⭐ Core Definition: Bone tumor

A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. There may be a lump, pain, or neurological signs from pressure. A bone tumor might present with a pathologic fracture. Other symptoms may include fatigue, fever, weight loss, anemia and nausea. Sometimes there are no symptoms and the tumour is found when investigating another problem.

Diagnosis is generally by X-ray and other radiological tests such as CT scan, MRI, PET scan and bone scintigraphy. Blood tests might include a complete blood count, inflammatory markers, serum electrophoresis, PSA, kidney function and liver function. Urine may be tested for Bence Jones protein. For confirmation of diagnosis, a biopsy for histological evaluation might be required.

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👉 Bone tumor in the context of Leukocytosis

Leukocytosis is a condition in which the white cell (leukocyte) count is above the normal range in the blood. It is frequently a sign of an inflammatory response, most commonly the result of infection, but may also occur following certain parasitic infections or bone tumors as well as leukemia. It may also occur after strenuous exercise, convulsions such as epilepsy, emotional stress, pregnancy and labor, anesthesia, as a side effect of medication (e.g., lithium), and epinephrine administration. There are five principal types of leukocytosis: neutrophilia (the most common form), lymphocytosis, monocytosis, eosinophilia, and basophilia.

This increase in leukocyte (primarily neutrophils) is usually accompanied by a "left upper shift" in the ratio of immature to mature neutrophils and macrophages. The proportion of immature leukocytes increases due to proliferation and inhibition of granulocyte and monocyte precursors in the bone marrow which is stimulated by several products of inflammation including C3a and G-CSF.Although it may indicate illness, leukocytosis is considered a laboratory finding instead of a separate disease. This classification is similar to that of fever, which is also a test result instead of a disease."Right shift" in the ratio of immature to mature neutrophils is considered with reduced count or lack of "young neutrophils" (metamyelocytes, and band neutrophils) in blood smear, associated with the presence of "giant neutrophils". This fact shows suppression of bone marrow activity, as a hematological sign specific for pernicious anemia and radiation sickness.

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Bone tumor in the context of Compression fracture

A compression fracture is a collapse of a vertebra. It may be due to trauma or due to a weakening of the vertebra (compare with burst fracture). This weakening is seen in patients with osteoporosis or osteogenesis imperfecta, lytic lesions from metastatic or primary tumors, or infection. In healthy patients, it is most often seen in individuals suffering extreme vertical shocks, such as ejecting from an ejection seat. Seen in lateral views in plain x-ray films, compression fractures of the spine characteristically appear as wedge deformities, with greater loss of height anteriorly than posteriorly and intact pedicles in the anteroposterior view.

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Bone tumor in the context of Forensic anthropology

Forensic anthropology is the application of the anatomical science of anthropology and its various subfields, including forensic archaeology and forensic taphonomy, in a legal setting. A forensic anthropologist can assist in the identification of deceased individuals whose remains are decomposed, burned, mutilated or otherwise unrecognizable, as might happen in a plane crash. Forensic anthropologists are also instrumental in the investigation and documentation of genocide and mass graves. Along with forensic pathologists, forensic dentists, and homicide investigators, forensic anthropologists commonly testify in court as expert witnesses. Using physical markers present on a skeleton, a forensic anthropologist can potentially determine a person's age, sex, stature, and race. In addition to identifying physical characteristics of the individual, forensic anthropologists can use skeletal abnormalities to potentially determine cause of death, past trauma such as broken bones or medical procedures, as well as diseases such as bone cancer.

The methods used to identify a person from a skeleton relies on the past contributions of various anthropologists and the study of human skeletal differences. Through the collection of thousands of specimens and the analysis of differences within a population, estimations can be made based on physical characteristics. Through these, a set of remains can potentially be identified. The field of forensic anthropology grew during the twentieth century into a fully recognized forensic specialty involving trained anthropologists as well as numerous research institutions gathering data on decomposition and the effects it can have on the skeleton.

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LINKED FROM (PARENTS)
← Compression fracture ← Forensic anthropology ← Leukocytosis
LINKS TO (CHILDREN)
Neoplastic → Bone → Benign → Malignant → Lung cancer → Breast cancer → Thyroid cancer → Kidney cancer → Prostate cancer → Focal neurologic signs → Pathologic fracture → Fatigue → Fever → Weight loss → Anemia → Nausea → Projectional radiography → Radiography → CT scan → MRI → Positron emission tomography → Bone scintigraphy → Complete blood count → Gel electrophoresis of proteins → Prostate-specific antigen → Kidney function → Liver function → Bence Jones protein → Biopsy → Histopathology →