Berkeley County, West Virginia in the context of "Eastern Panhandle of West Virginia"

The Hagerstown–Martinsburg metropolitan area, officially designated by the United States Office of Management and Budget (OMB) as Hagerstown–Martinsburg, Maryland–West Virginia Metropolitan Statistical Area (MSA), constitutes the primary cities of Hagerstown, Maryland; Martinsburg, West Virginia; and surrounding areas in three counties: Washington County, Maryland; Berkeley County, West Virginia; and Morgan County, West Virginia. The metro area lies mainly within the rich, fertile Cumberland and Shenandoah Valleys and is approximately a 60–90 minute drive from Washington, D.C.; Baltimore, Maryland; and Harrisburg, Pennsylvania; Hagerstown is approximately 75 miles (121 km) driving distance from all three cities. The population of the metropolitan area as of 2008 is 263,753.

Morgan County is a county located in the U.S. state of West Virginia. As of the 2020 census, the population was 17,063. Its county seat is Berkeley Springs. The county was formed in 1820 from parts of Hampshire and Berkeley Counties and named in honor of General Daniel Morgan, prominent soldier of the American Revolutionary War. The county and Town of Bath are considered excellent jumping-off points for exploring the Potomac and Cacapon Rivers just to the north and west, respectively. Also, the county is a tourist destination hosting numerous local artists, mineral water spas, and a large amount of outdoor recreation that includes fishing, boating, wildlife, hunting, and mountain scenery. The region is known for the famed Apple Butter Festival, which is annually held in October. Morgan County is also the home of an important silica mine, part of U.S. Silica.

Martinsburg is a city in Berkeley County, West Virginia, United States, and its county seat. The population was 18,773 at the 2020 census, making Martinsburg the largest city in the eastern panhandle of West Virginia and the sixth-most populous city in the state. It is a principal city of the Hagerstown–Martinsburg metropolitan area extending into Maryland, which had 293,844 residents in 2020.

Interstate 81 (I-81) is an 855.02-mile-long (1,376.02 km) Interstate Highway. In the US state of Virginia, I-81 runs for 324.92 miles (522.91 km), making the portion in Virginia longer than any other state's portion of the route. It is also the longest Interstate Highway within the borders of Virginia. It stretches from the Tennessee state line near Bristol to the West Virginia state line near Winchester. It enters Virginia from Bristol, Tennessee, and leaves Virginia into Berkeley County, West Virginia. The route passes through the cities of Bristol, Roanoke, Salem, Lexington, Staunton, and Harrisonburg.