Basilica of Our Lady of Guadalupe in the context of "Malinalco"

Our Lady of Guadalupe (Spanish: Nuestra Señora de Guadalupe), also known as the Virgin of Guadalupe (Spanish: Virgen de Guadalupe), is a Catholic title of the Blessed Virgin Mary associated with four Marian apparitions to Juan Diego and one to his uncle, Juan Bernardino reported in December 1531, when the Mexican territories were part of the Spanish Empire.

A venerated image on a cloak (tilmahtli) associated with the apparition is enshrined in the Basilica of Our Lady of Guadalupe in Mexico City.

Colonia Villa de Guadalupe (also known as La Villa de Guadalupe Hidalgo) is a former separate town, now a neighborhood in northern Mexico City which, in 1531, was the site of the alleged apparition of Our Lady of Guadalupe, the most renowned Marian apparition in the Americas. She is venerated in the Our Lady of Guadalupe Shrine, located in the villa (town).

The word Guadalupe comes from Spain, where it was originally the name of a river.

Juan Diego Cuauhtlatoatzin (1474–1548), also known simply as Juan Diego (Spanish pronunciation: [ˌxwanˈdjeɣo]), was a Nahua peasant and Marian visionary. He is said to have been granted apparitions of Our Lady of Guadalupe on four occasions in December 1531: three at the hill of Tepeyac and a fourth before don Juan de Zumárraga, then the first bishop of Mexico. The Basilica of Our Lady of Guadalupe, located at the foot of Tepeyac, houses the cloak (tilmahtli) that is traditionally said to be Juan Diego's, and upon which the image of the Virgin is said to have been miraculously impressed as proof of the authenticity of the apparitions.

Juan Diego's visions and the imparting of the miraculous image, as recounted in oral and written colonial sources such as the Huei tlamahuiçoltica, are together known as the Guadalupe event (Spanish: el acontecimiento Guadalupano), and are the basis of the veneration of Our Lady of Guadalupe. This veneration is ubiquitous in Mexico, prevalent throughout the Spanish-speaking Americas, and increasingly widespread beyond. As a result, the Basilica of Our Lady of Guadalupe is now one of the world's major Christian pilgrimage destinations, receiving 22 million visitors in 2010.