Vileyka Region (Belarusian: Вілейская вобласць, romanized: Viliejskaja voblasc; Russian: Вилейская область, romanized: Vileyskaya oblast) was a territorial entity in the Byelorussian Soviet Socialist Republic created on 4 December 1939 out of the eastern powiats of the Wilno Voivodeship after the Soviet annexation of Western Belorussia of (then part of the Kresy Zachodnie region in Poland) into the Byelorussian SSR on 14 November 1939. The administrative centre of the region was the city of Vileyka.
Initially the region consisted of Vileyka, Ashmyany, Braslaw, Dzisna, Pastavy, and Sventiany districts. In January 1940, it consisted of 22 districts: Astravyets, Ashmyany, Braslaw, Vidzy, Gadutsishki, Hlybokaye, Dzisna, Dokshytsy, Dunilavichy, Ilya, Kryvichy, Kuraniets, Maladzyechna, Miory, Miadzieł, Pastavy, Plisa, Radashkovichy, Smarhon, Sventiany, Svir and Sharkawshchyna. In November 1940, the Gadutsishki and Sventiany districts, as well as parts of the Astravyets, Ashmyany, Pastavy and Svir districts were transferred to the Lithuanian SSR. Also, during the German occupation between 1941 and 1944, Ashmyany District was part of Wilna Land General Bezirk at Litauen and the city of Vileyka Glubokoye was part of General Bezirk Weissruthenien in Reichskommissariat Ostland.