Apollo 4 in the context of Vehicle Assembly Building

As part of the Apollo program by NASA, 24 astronauts flew nine missions to the Moon between December 1968 and December 1972. During six successful two-man landing missions, twelve men walked on the lunar surface, six of whom drove Lunar Roving Vehicles as part of the last three missions. Three men have been to the Moon twice, one orbited once and took a circumlunar trajectory the second time, while the other two landed once apiece. Apart from these 24 men, no human being has gone beyond low Earth orbit. As of December 2025, five of the 24 remain alive. A number of non-human animals have circled or orbited it, including two tortoises, several turtles, and five mice.

Apollo missions 8 and 10–17 were the nine crewed missions to the Moon. Apollo 4–6 and AS-201 and AS-202 were uncrewed, while AS-203 is considered a test flight. The Apollo program included three other crewed missions: Apollo 1 (AS-204) did not launch and its crew died in a ground-based capsule fire, while Apollo 7 and Apollo 9 were low Earth orbit missions that tested spacecraft components and docking maneuvers. Apollo missions 18, 19, and 20 were canceled. Twelve astronauts later flew unused Apollo command modules in the Apollo Applications Program's Skylab and Apollo–Soyuz Test Project. Of the 24 astronauts who flew to the Moon, two went on to command a Skylab mission, one commanded Apollo–Soyuz, one flew as commander for Approach and Landing Tests of the Space Shuttle, and two commanded orbital Space Shuttle missions.

Apollo 6 (April 4, 1968), also known as AS-502, was the third and final uncrewed flight in the United States' Apollo Program and the second test of the Saturn V launch vehicle. It qualified the Saturn V for use on crewed missions, and it was used beginning with Apollo 8 in December 1968.

Apollo 6 was intended to demonstrate the ability of the Saturn V's third stage, the S-IVB, to propel itself and the Apollo spacecraft to lunar distances. Its components began arriving at the Kennedy Space Center in early 1967. Testing proceeded slowly, often delayed by testing of the Saturn V intended for Apollo 4—the inaugural launch of the Saturn V. After that uncrewed mission launched in November 1967, there were fewer delays, but enough so that the flight was postponed from March to April 1968.