Antiretroviral drug in the context of Opportunistic infections

UNICEF (/ˈjuːniˌsɛf/ YOO-nee-SEF), originally the United Nations International Children's Emergency Fund, officially United Nations Children's Fund since 1953, is an agency of the United Nations responsible for providing humanitarian and developmental aid to children worldwide. The organization is one of the most widely known and visible social welfare entities globally, operating in 192 countries and territories. UNICEF's activities include providing immunizations and disease prevention, administering treatment for children and mothers with HIV, enhancing childhood and maternal nutrition, improving sanitation, promoting education, and providing emergency relief in response to disasters.

UNICEF is the successor of the United Nations International Children's Emergency Fund, and was created on 11 December 1946, in New York, by the U.N. Relief Rehabilitation Administration to provide immediate relief to children and mothers affected by World War II. The same year, the United Nations General Assembly established UNICEF to further institutionalize post-war relief work. In 1950, its mandate was extended to address the long-term needs of children and women, particularly in developing countries. In 1953, the organization became a permanent part of the United Nations System, and its name was changed to United Nations Children's Fund, though it retains the UNICEF acronym.

HIV/AIDS denialism is the belief, despite evidence to the contrary, that the human immunodeficiency virus (HIV) does not cause acquired immune deficiency syndrome (AIDS). Some of its proponents reject the existence of HIV, while others accept that HIV exists but argue that it is a harmless passenger virus and not the cause of AIDS. Insofar as they acknowledge AIDS as a real disease, they attribute it to some combination of sexual behavior, recreational drugs, malnutrition, poor sanitation, haemophilia, or the effects of the medications used to treat HIV infection (antiretrovirals).

The scientific consensus is that the evidence showing HIV to be the cause of AIDS is conclusive and that HIV/AIDS denialist claims are pseudoscience based on conspiracy theories, faulty reasoning, cherry picking, and misrepresentation of mainly outdated scientific data. As evidence mounted against denialism, combined with those with HIV/AIDS living much longer, these claims stopped being believed. With the rejection of these arguments by the scientific community, HIV/AIDS denialist material is now targeted at less scientifically sophisticated audiences and spread mainly through the Internet, increased substantially since the COVID-19 pandemic.

The term morbilliform refers to a rash that looks like measles. The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. A morbilliform rash is a rose-red flat (macular) or slightly elevated (maculopapular) eruption, showing circular or elliptical lesions varying in diameter from 1 to 3 mm, with healthy-looking skin intervening.

Patients with measles will have the rash but there are other syndromes and infections that will display the same symptom such as patients with Kawasaki disease, meningococcal petechiae or Waterhouse-Friderichsen syndrome, Dengue, Roseola, congenital syphilis, rubella, Echovirus 9, drug hypersensitivity reactions (in particular with certain classes of antiretroviral drugs, such as abacavir and nevirapine, and also the antiepileptic drug phenytoin), or other conditions may also have a morbilliform rash. It is usually present in drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) following a prodrome of fever, malaise, throat pain with dysphagia, and itching. It has also been mentioned as a possible manifestation of onset or recovery from COVID-19.