Anti-Müllerian hormone in the context of "PCOD"

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👉 Anti-Müllerian hormone in the context of PCOD

Polycystic ovary syndrome (PCOS) is the most common hormonal disorder in women of reproductive age. The name comes from the observation of small follicles (or "cysts") that often appear on the ovaries. However, not everyone with PCOS has these follicles, and they are not the cause of the condition.

PCOS is diagnosed when a person has at least two of the following three features: irregular menstrual periods, high testosterone or related symptoms (like excess facial hair), or polycystic ovaries found on an ultrasound. A blood test for high levels of anti-Müllerian hormone can replace the ultrasound in the diagnosis. Other symptoms associated with PCOS are heavy periods, acne, difficulty getting pregnant, and patches of darker skin.

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👉 Anti-Müllerian hormone in the context of PCOD
Anti-Müllerian hormone in the context of SRY

Anti-Müllerian hormone in the context of SRY

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.

SRY is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the steroidogenic factor 1 (SF-1) protein, SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone. Effects of the SRY gene, which normally take place 6–8 weeks after fetus formation, inhibit the growth of female anatomical structure in males. The gene also contributes towards developing the secondary sexual characteristics of males.

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