Anomeric in the context of "Nucleosides"


Anomeric in the context of "Nucleosides"

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⭐ Core Definition: Anomeric

In carbohydrate chemistry, anomers (from Greek ἄνω 'up, above' and μέρος 'part') are specific types of stereoisomers found in sugars.

Many common sugars, such as glucose, exist in both a linear (or open-chain) form and a cyclic (or ring) form. The ring is formed when one end of the sugar molecule connects to the other end. The carbon atom where this ring closure occurs is called the anomeric carbon. Depending on the direction from which the connection is made, this anomeric carbon can have its new group (–OH) pointing in one of two distinct orientations, typically visualized as "up" or "down" in a standard diagram. These two resulting molecules are the anomers and are labeled with the Greek letters alpha (α) or beta (β).

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👉 Anomeric in the context of Nucleosides

Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups. In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building blocks of DNA and RNA.

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