Amber Tamblyn in the context of "Independent Spirit Awards"

House (also known as House, M.D.) is an American medical drama television series created by David Shore that originally aired on Fox from November 16, 2004, to May 21, 2012, for eight seasons. It features the life of Dr. Gregory House (Hugh Laurie), an unconventional, misanthropic, cynical medical genius who, despite his dependence on pain medication, successfully leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey. House often clashes with his fellow physicians, including his own diagnostic team, because many of his hypotheses about patients' illnesses are based on subtle or controversial insights, and his flouting of hospital rules and procedures frequently leads him into conflict with his boss, hospital administrator and Dean of Medicine Dr. Lisa Cuddy (Lisa Edelstein). House's only true friend is Dr. James Wilson (Robert Sean Leonard), head of the Department of Oncology.

During the first three seasons, House's diagnostic team consists of Dr. Robert Chase (Jesse Spencer), Dr. Allison Cameron (Jennifer Morrison), and Dr. Eric Foreman (Omar Epps). At the end of the third season, this team disbands. Rejoined by Foreman, House gradually selects three new team members: Dr. Remy "Thirteen" Hadley (Olivia Wilde), Dr. Chris Taub (Peter Jacobson), and Dr. Lawrence Kutner (Kal Penn). Chase and Cameron continue to appear occasionally in different roles at the hospital. Kutner dies late in season five; early in season six, Cameron departs the hospital, and Chase returns to the diagnostic team. Thirteen takes a leave of absence for most of season seven, and her position is filled by medical student Martha M. Masters (Amber Tamblyn). Cuddy and Masters depart before season eight; Foreman becomes the new Dean of Medicine, while Dr. Jessica Adams (Odette Annable) and Dr. Chi Park (Lo Mutuc, credited as Charlyne Yi) join House's team.

127 Hours is a 2010 biographical drama film co-written, produced, and directed by Danny Boyle. The film mainly stars James Franco, with Kate Mara, Amber Tamblyn, and Clémence Poésy appearing in brief supporting roles. In the film, canyoneer Aron Ralston must find a way to escape after he gets trapped by a boulder in an isolated slot canyon in Bluejohn Canyon, southeastern Utah, in April 2003. It is a British and American venture produced by Pathé, Everest Entertainment, Film4 Productions, HandMade Films and Cloud Eight Films.

The film, based on Ralston's memoir Between a Rock and a Hard Place (2004), was written by Boyle and Simon Beaufoy, co-produced by Christian Colson and John Smithson, and scored by A. R. Rahman. Beaufoy, Colson, and Rahman had all previously worked with Boyle on Slumdog Millionaire (2008). 127 Hours premiered at the Telluride Film Festival on 4 September 2010, and was released in the United States on 5 November 2010 and in the United Kingdom on 7 January 2011. It was acclaimed by critics and audiences and grossed $60.7 million worldwide. It was selected by the American Film Institute as one of the top 10 films of 2010 and was nominated for six Academy Awards, including Best Actor for Franco and Best Picture. The film also received nominations for eight British Academy Film Awards and three Golden Globe Awards.

The eighth and final season of House was ordered on May 10, 2011. It premiered on October 3, 2011. It was the only season not to feature Lisa Edelstein as Dr. Lisa Cuddy. Olivia Wilde (Dr. Remy "Thirteen" Hadley) also left the show after the third episode to further her film career, although she returned at the end of the series. On January 8, 2012, Fox's President of Entertainment, Kevin Reilly, stated that the network had been "avoiding" a decision on the fate of the series, as it was "hard to imagine the network without House" and that the decision on the future of the series would be a "close call". Hugh Laurie's contract on House expired at the end of the eighth season. Laurie stated that once House was over, he would be moving on to strictly film roles. On February 8, 2012, in a joint statement issued by Fox and executive producers David Shore, Katie Jacobs, and Laurie, it was revealed that the season would be the last for House.

It was announced that Shore would direct and co-write the final episode of the show and also that Wilde would return as Thirteen for the penultimate episode and the series finale. Edelstein did not return for the series finale. Kal Penn was reported to be in talks and returned as Dr. Lawrence Kutner. Amber Tamblyn also appeared briefly as Martha M. Masters for the finale. Jennifer Morrison appeared in the finale in a cameo appearance as Allison Cameron. Anne Dudek, Sela Ward and Andre Braugher also reprised their previous recurring/guest roles as Amber Volakis, Stacy Warner, and Darryl Nolan, respectively. The series finale aired on May 21, following a retrospective episode titled "Swan Song".