Oswaldtwistle (/ˈɒzwəl.twɪzəl/ "ozzle twizzle") is a town in the Hyndburn borough of Lancashire, England, 3 miles (5 km) southeast of Blackburn, contiguous with Accrington. The town has a rich industrial heritage, being home to James Hargreaves, inventor of the spinning jenny, and Robert "Parsley" Peel of calico printing fame. The Leeds and Liverpool Canal passes through the town and was responsible for the export of much of the area's cotton produce.
At the 2011 census, it had a population of 11,803. In 2021 the population had decreased to 10,815