The 1st federal electoral district of Puebla (Spanish: Distrito electoral federal 01 de Puebla) is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of 16 such districts in the state of Puebla.
It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system. Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the fourth region.