The 16th century begins with the Julian year 1501 (MDI) and ends with either the Julian or the Gregorian year 1600 (MDC) (depending on the reckoning used; the Gregorian calendar introduced a lapse of 10 days in October 1582). The Habsburg Spanish Empire, Portuguese Empire, Ottoman Empire, Safavid Persia, Mughal India and Ming China were the most powerful and hegemonic states.
The Renaissance in Italy and Europe saw the emergence of important artists, authors and scientists, and led to the foundation of important subjects which include accounting and political science. Copernicus proposed the heliocentric universe, which was met with strong resistance, and Tycho Brahe refuted the theory of celestial spheres through observational measurement of the 1572 appearance of a Milky Way supernova. These events directly challenged the long-held notion of an immutable universe supported by Ptolemy and Aristotle, and led to major revolutions in astronomy and science. Galileo Galilei became a champion of the new sciences, invented the first thermometer and made substantial contributions in the fields of physics and astronomy, becoming a major figure in the Scientific Revolution in Europe.