Zoe Porphyrogenita (also spelled Zoë; Greek: Ζωή Πορφυρογέννητη, romanized: Zōē Porphyrogénnētē, Medieval Greek: [zoˈi] "life"; c. 978 – 1050) was a member of the Macedonian dynasty who briefly reigned as Byzantine empress in 1042, alongside her sister Theodora. Before that she was enthroned as empress consort or empress mother to a series of co-rulers, two of whom were married to her.
Zoe was born when her father Constantine was nominal co-emperor to his brother, Basil II. After a planned marriage to Holy Roman Emperor Otto III in 996 failed to materialise, Zoe spent subsequent years in the imperial palace. Her uncle Basil died in 1025 when Zoe was 47, and her father acceded the Byzantine throne as Constantine VIII. As he had no sons, Constantine hoped to continue the dynasty by marrying off one of his daughters. Zoe, aged 50, was married to Romanos Argyros. She and Romanos took the throne the next day on her father's death.