Vitamin D3 in the context of "Solar radiation"

Sunlight is the portion of the electromagnetic radiation which is emitted by the Sun (i.e. solar radiation) and received by the Earth, in particular the visible light perceptible to the human eye as well as invisible infrared (typically perceived by humans as warmth) and ultraviolet (which can have physiological effects such as sunburn) lights. However, according to the American Meteorological Society, there are "conflicting conventions as to whether all three [...] are referred to as light, or whether that term should only be applied to the visible portion of the spectrum". Upon reaching the Earth, sunlight is scattered and filtered through the Earth's atmosphere as daylight when the Sun is above the horizon. When direct solar radiation is not blocked by clouds, it is experienced as sunshine, a combination of bright light and radiant heat (atmospheric). When blocked by clouds or reflected off other objects, sunlight is diffused. Sources estimate a global average of between 164 watts to 340 watts per square meter over a 24-hour day; this figure is estimated by NASA to be about a quarter of Earth's average total solar irradiance.

The ultraviolet radiation in sunlight has both positive and negative health effects, as it is both a requisite for vitamin D₃ synthesis and a mutagen.

Calcium ions (Ca) contribute to the physiology and biochemistry of organisms' cells. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization. Many enzymes require calcium ions as a cofactor, including several of the coagulation factors. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

Plasma calcium levels in mammals are tightly regulated, with bone acting as the major mineral storage site. Calcium ions, Ca, are released from bone into the bloodstream under controlled conditions. Calcium is transported through the bloodstream as dissolved ions or bound to proteins such as serum albumin. Parathyroid hormone secreted by the parathyroid gland regulates the resorption of Ca from bone, reabsorption in the kidney back into circulation, and increases in the activation of vitamin D₃ to calcitriol. Calcitriol, the active form of vitamin D₃, promotes absorption of calcium from the intestines and bones. Calcitriol also plays a key role in upregulating levels of intracellular calcium, and high levels of this ion appear to be protective against cancers of the breast and prostate. The suppression of calcitriol by excessive dietary calcium is believed to be the major mechanism for the potential link between dairy and cancer. However, the vitamin D present in many dairy products may help compensate for this deleterious effect of high-calcium diets by increasing serum calcitriol levels. Calcitonin secreted from the parafollicular cells of the thyroid gland also affects calcium levels by opposing parathyroid hormone; however, its physiological significance in humans is in dispute.

Exposure of skin to ultraviolet radiation from sunlight presents both positive and negative health effects. On the positive side, UV exposure enables the synthesis of vitamin D₃, which is essential for bone health and potentially plays a role in inhibiting certain cancers. While vitamin D can also be obtained through dietary supplements, UV exposure offers benefits such as enhanced subdermal nitric oxide production and improved endorphin levels, which are not achievable through supplementation alone. Additionally, exposure to visible light supports melatonin synthesis, maintains circadian rhythms, and reduces the risk of seasonal affective disorder.

However, UV radiation is also a mutagen and carcinogen for the skin, posing significant risks. Acute exposure can lead to painful sunburns and increase the likelihood of developing serious skin conditions later in life. Prolonged exposure is associated with the development of skin cancers, photoaging or premature skin aging, immune suppression, and eye diseases like cataracts.